三氯蔗糖甜味剂对大鼠血液成分放射性标记、红细胞形态及放射性药物生物分布的体内影响。
Sucralose sweetener in vivo effects on blood constituents radiolabeling, red blood cell morphology and radiopharmaceutical biodistribution in rats.
作者信息
Rocha G S, Pereira M O, Benarroz M O, Frydman J N G, Rocha V C, Pereira M J, Fonseca A S, Medeiros A C, Bernardo-Filho M
机构信息
Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, Avenida 28 de Setembro, 87, Vila Isabel, 20551030 Rio de Janeiro, Brazil.
出版信息
Appl Radiat Isot. 2011 Jan;69(1):46-51. doi: 10.1016/j.apradiso.2010.08.009. Epub 2010 Aug 17.
Effects of sucralose sweetener on blood constituents labelled with technetium-99m ((99m)Tc) on red blood cell (RBC) morphology, sodium pertechnetate (Na(99m)TcO(4)) and diethylenetriaminepentaacetic acid labeled with (99m)Tc ((99m)Tc-DTPA) biodistribution in rats were evaluated. Radiolabeling on blood constituents from Wistar rats was undertaken for determining the activity percentage (%ATI) on blood constituents. RBC morphology was also evaluated. Na(99m)TcO(4) and (99m)Tc-DTPA biodistribution was used to determine %ATI/g in organs. There was no alteration on RBC blood constituents and morphology %ATI. Sucralose sweetener was capable of altering %ATI/g of the radiopharmaceuticals in different organs. These findings are associated to the sucralose sweetener in specific organs.
评估了三氯蔗糖甜味剂对用锝-99m（99mTc）标记的血液成分、红细胞（RBC）形态、高锝酸钠（Na99mTcO4）以及用99mTc标记的二乙烯三胺五乙酸（99mTc-DTPA）在大鼠体内生物分布的影响。对Wistar大鼠的血液成分进行放射性标记，以确定血液成分上的活性百分比（%ATI）。还评估了RBC形态。使用Na99mTcO4和99mTc-DTPA的生物分布来确定器官中的%ATI/g。RBC血液成分和形态%ATI没有改变。三氯蔗糖甜味剂能够改变不同器官中放射性药物的%ATI/g。这些发现与特定器官中的三氯蔗糖甜味剂有关。
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