Jaiswal D M, Belsare D K
Acta Biol Med Ger. 1976;35(6):757-61.
A single injection of salicylate or salicylate plus ACTH was able to lower the hepatic cholesterol content within one hour after the treatment. However, their daily injection for eight days caused significant rise in the hepatic cholesterol. ACTH alone could not significantly alter the liver cholesterol content after similar treatment. A single injection of salicylate produced hypocholesterolemia within one and three hours after the treatment. ACTH or salicylate plus ACTH also brought about 50 per cent reduction in serum cholesterol level from its initial control value within one hour. Similar treatments, however, raised the serum cholesterol after three hours. The rise in the serum cholesterol level was about twofold in animals five hours after salicylate plus ACTH treatment. Daily administration of salicylate, ACTH or salicylate plus ACTH for eight days caused, however, hypocholesterolemia.
单次注射水杨酸盐或水杨酸盐加促肾上腺皮质激素（ACTH）能够在治疗后一小时内降低肝脏胆固醇含量。然而，连续八天每日注射会导致肝脏胆固醇显著升高。单独使用ACTH在类似治疗后不会显著改变肝脏胆固醇含量。单次注射水杨酸盐在治疗后一至三小时内产生低胆固醇血症。ACTH或水杨酸盐加ACTH也能在一小时内使血清胆固醇水平从初始对照值降低50%。然而，类似治疗在三小时后会使血清胆固醇升高。在水杨酸盐加ACTH治疗五小时后，动物血清胆固醇水平升高约两倍。然而，连续八天每日给予水杨酸盐、ACTH或水杨酸盐加ACTH会导致低胆固醇血症。
