Han K, Levenspiel O
Department of Chemical Engineering, Oregon State University, Corvallis, Oregon 97331, USA.
Biotechnol Bioeng. 1988 Aug 5;32(4):430-47. doi: 10.1002/bit.260320404.
A generalized form of Monod kinetics is proposed to account for all kinds of product, cell, and substrate inhibition. This model assumes that there exists a critical inhibitor concentration above which cells cannot grow, and that the constants of the Monod equation are functions of this limiting inhibitor concentration. Methods for evaluating the constants of this rate form are presented. Finally the proposed kinetic form is compared with the available data in the literature, which unfortunately is very sparse. In all cases, this equation form fitted the data very well.
提出了一种广义的莫诺德动力学形式，以解释各种产物、细胞和底物抑制作用。该模型假设存在一个临界抑制剂浓度，高于此浓度细胞无法生长，且莫诺德方程的常数是该极限抑制剂浓度的函数。给出了评估这种速率形式常数的方法。最后，将所提出的动力学形式与文献中现有的数据进行了比较，遗憾的是这些数据非常稀少。在所有情况下，这种方程形式都能很好地拟合数据。
