Medeiros K C P, Figueiredo C A V, Figueredo T B, Freire K R L, Santos F A R, Alcantara-Neves N M, Silva T M S, Piuvezam M R
Laboratório de Tecnologia Farmacêutica, Centro de Ciências da Saúde, Universidade Federal da Paraíba, UFPB, Brazil.
J Ethnopharmacol. 2008 Sep 2;119(1):41-6. doi: 10.1016/j.jep.2008.05.036. Epub 2008 Jun 6.
The bee pollen is used in folk medicine to alleviate allergic reactions. The bee pollen phenolic extract (BPPE) consists in phenolic compounds (flavonoids) from plants picked by Apis mellifera bee.
Here we evaluated the anti-allergic property of the BPPE and the flavonoid myricetin (MYR) in murine model of ovalbumin (OVA)-induced allergy.
The study focused on the BPPE or myricetin treatment of OVA-sensitized BALB/c mice and their effects on the IgE and IgG1 production, pulmonary cell migration, eosinophil peroxidase (EPO) activity and anaphylactic shock reaction.
The BPPE treatment (200mg/kg) showed inhibition of the paw edema, IgE and IgG(1) OVA-specific production, leukocyte migration to the bronchoalveolar lavage (BAL) and EPO activity in lungs. In addition, BPPE treatment showed partial protection on the anaphylactic shock reaction induced by OVA. Treatment with myricetin (5 mg/kg) also inhibited pulmonary cell migration and IgE and IgG(1) OVA-specific production.
These results support the hypothesis the myricetin is one of the flavonoids of BPPE responsible for the anti-allergic effect and a potential tool to treat allergies.
蜂花粉在民间医学中用于缓解过敏反应。蜂花粉酚提取物（BPPE）由蜜蜂采集的植物中的酚类化合物（黄酮类）组成。
在此，我们在卵清蛋白（OVA）诱导的过敏小鼠模型中评估了BPPE和黄酮类化合物杨梅素（MYR）的抗过敏特性。
该研究聚焦于用BPPE或杨梅素处理OVA致敏的BALB/c小鼠，以及它们对IgE和IgG1产生、肺细胞迁移、嗜酸性粒细胞过氧化物酶（EPO）活性和过敏反应的影响。
BPPE处理（200mg/kg）显示出对爪部水肿、IgE和IgG（1）OVA特异性产生、白细胞向支气管肺泡灌洗（BAL）的迁移以及肺中EPO活性的抑制作用。此外，BPPE处理对OVA诱导的过敏反应显示出部分保护作用。用杨梅素（5mg/kg）处理也抑制了肺细胞迁移以及IgE和IgG（1）OVA特异性产生。
这些结果支持以下假设，即杨梅素是BPPE中负责抗过敏作用的黄酮类化合物之一，是治疗过敏的一种潜在工具。
