大鼠前列腺肿瘤表达癌促凝素，一种凝血因子X的激活剂。
Rat prostate tumors express cancer procoagulant, an activator of coagulation factor X.
作者信息
Kamocka Malgorzata, Pollard Morris, Suckow Mark, Mielicki Wojciech P, Rosen Elliot D
机构信息
Medical University of Lodz, Lodz, Poland.
出版信息
Comp Med. 2008 Jun;58(3):282-6.
Two common procoagulant activities associated with tumors are tissue factor and cancer procoagulant (CP), an activator of coagulation factor X. We have identified a convenient source of CP in transplanted Lobund-Wistar rat PA3 prostate tumors. CP activity was purified from 5 independent transplanted prostate tumors by column chromatography. The protein activated factor X in the absence of TF and factor VII. An antihuman CP antibody recognized rat CP in an ELISA and inactivated CP activity in a chromogenic assay. Lobund-Wistar prostate tumors may provide a convenient animal model useful in determining the role of CP in cancer development.
与肿瘤相关的两种常见促凝活性是组织因子和癌促凝素（CP），后者是凝血因子X的激活剂。我们在移植的Lobund-Wistar大鼠PA3前列腺肿瘤中发现了CP的便利来源。通过柱色谱法从5个独立移植的前列腺肿瘤中纯化出CP活性。该蛋白在没有组织因子和因子VII的情况下激活因子X。一种抗人CP抗体在ELISA中识别大鼠CP，并在显色测定中使CP活性失活。Lobund-Wistar前列腺肿瘤可能提供一种便利的动物模型，有助于确定CP在癌症发展中的作用。
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