Senthamizhchelvan Srinivasan, Pant G S, Rath G K, Julka P K, Nair O
Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari nagar, New Delhi 110 029, India.
Phys Med. 2009 Jun;25(2):82-7. doi: 10.1016/j.ejmp.2008.05.004. Epub 2008 Jun 30.
Biological dosimetry provides information on the absorbed dose and its distribution in the body for an early assessment of irradiation consequences in exposed individuals. In this study, an effort has been made to see the applicability of biological dosimetry using micronuclei assay for dose estimation in therapeutic irradiation of cancer patients in acute high dose partial body irradiation. Dose estimation in partial body irradiations was done on the basis of Dolphin's contaminated Poisson method, using the in vitro dose response calibration curve. The equivalent whole body dose and the dose to the irradiated part of the body were estimated to be 1.8+/-0.1 Gy and 6.4+/-0.3 Gy, respectively. The estimated percentage of irradiated blood and the fraction of cells exposed were 41.5+/-1.6% and 10.4+/-0.8%, respectively. The estimated fraction of irradiated cells was comparable with the actual volume of irradiation.
生物剂量测定可为早期评估受照个体的辐射后果提供有关吸收剂量及其在体内分布的信息。在本研究中，已尝试观察使用微核试验进行生物剂量测定在癌症患者急性高剂量局部身体照射的治疗性辐射中进行剂量估算的适用性。局部身体照射的剂量估算是基于Dolphin的污染泊松方法，使用体外剂量反应校准曲线进行的。等效全身剂量和身体受照部位的剂量估计分别为1.8±0.1 Gy和6.4±0.3 Gy。估计的受照血液百分比和暴露细胞分数分别为41.5±1.6%和10.4±0.8%。估计的受照细胞分数与实际照射体积相当。
