亚抑菌浓度抗生素对金黄色葡萄球菌中SOS和DNA修复基因表达的影响。
Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
作者信息
Mesak Lili Rosana, Miao Vivian, Davies Julian
机构信息
Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Antimicrob Agents Chemother. 2008 Sep;52(9):3394-7. doi: 10.1128/AAC.01599-07. Epub 2008 Jun 30.
Abstract
Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.
摘要
构建了带有不同SOS反应和DNA修复相关启动子-荧光素酶基因融合构建体的金黄色葡萄球菌报告克隆，以研究亚抑菌浓度抗生素对SOS和甲基错配修复（MMR）基因转录的影响。氟喹诺酮类药物（FQs）上调了SOS和MMR基因。在耐FQ突变体中，抗生素诱导的转录调控模式发生了改变。
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