Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain.
Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, E-37008 Salamanca, Spain.
Mar Drugs. 2018 Jan 1;16(1):6. doi: 10.3390/md16010006.
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure-activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields.
本文综述了结构中具有嘌呤基序的海洋次生代谢产物。根据烷基取代基的大小及其在嘌呤环上的位置，对烷基嘌呤进行了分组。本文综合考虑了海洋来源、化学结构和生物活性等方面，以及天然产物和生物活性类似物的合成方法。本文为这些代谢物的结构-活性关系研究提供了参考，并强调了海洋作为多种治疗领域新先导化合物来源的潜力。
