Martinez-Devesa Pablo, Barnes Martyn L, Milford Chris A
Department of Otolaryngology, John Radcliffe Hospital, Oxford, United Kingdom.
Skull Base. 2008 Jan;18(1):1-8. doi: 10.1055/s-2007-992766.
To evaluate the management of patients with malignant tumors of the ear and temporal bone.
Retrospective analysis of data.
Radcliffe Infirmary, Oxford, United Kingdom.
Twenty-seven patients were classified into two groups according to the site of origin of the tumor: (1) superficial (17 tumors): tumors arising from the skin of the pinna, parotid, and temporomandibular joint area; (2) deep (10 tumors): tumors arising in the ear canal and temporal bone.
Treatment modality, complications, recurrence rate, disease-free interval, and survival.
The mean follow-up period was 25 months (0 to 60), and the median overall survival 46 months (0 to 102). Complications occurred in 6 patients (22%). The 3-year survival was 38% (95% confidence interval [CI], 19 to 58%), and the 5-year survival 19% (95% CI, 3 to 35%).
There were insufficient data to demonstrate any difference in survival or disease-free interval related to the site of tumor origin (superficial versus deep tumors). There were independent differences in survival in favor of both performing parotidectomy and using postoperative radiotherapy, but neither reached significance at the 0.05 level.
评估耳部及颞骨恶性肿瘤患者的治疗情况。
数据回顾性分析。
英国牛津拉德克利夫医院。
27例患者根据肿瘤起源部位分为两组：（1）浅表组（17例肿瘤）：起源于耳廓皮肤、腮腺及颞下颌关节区域的肿瘤；（2）深部组（10例肿瘤）：起源于耳道及颞骨的肿瘤。
治疗方式、并发症、复发率、无病生存期及生存率。
平均随访期为25个月（0至60个月），总生存期中位数为46个月（0至102个月）。6例患者（22%）出现并发症。3年生存率为38%（95%置信区间[CI]，19%至58%），5年生存率为19%（95%CI，3%至35%）。
尚无足够数据表明肿瘤起源部位（浅表肿瘤与深部肿瘤）在生存率或无病生存期方面存在差异。行腮腺切除术及术后放疗在生存率方面均有独立差异，但在0.05水平均未达到显著差异。
