Wierzbicka Małgorzata, Niemczyk Kazimierz, Bruzgielewicz Antoni, Durko Marcin, Klatka Janusz, Kopeć Tomasz, Osuch-Wójcikiewicz Ewa, Pietruszewska Wioletta, Szymański Marcin, Szyfter Witold
ENT Department, Medical University, Poznań, Poland.
ENT Department, Medical University, Warsaw, Poland.
PLoS One. 2017 Feb 22;12(2):e0169399. doi: 10.1371/journal.pone.0169399. eCollection 2017.
To present outcomes of extensive surgery: lateral, subtotal, total petrosectomies in patients with temporal bone invasion resulting from specific primary cancers.
Retrospective case review.
Four tertiary referral centers.
89 patients with cancer of the temporal bone treated between January 2006 and December 2010.
Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy.
Disease-specific survival, overall survival.
In 27.0% of the patients, relapse was reported, with an average of 6.3 months after surgery; 31 patients (34.8%) died during the follow-up. The average mortality was 22.1 months. Fifty-four patients (58.7%) stayed alive during the time of observation. The average survival time was 42.0 months. The median time of survival with relapse was 12 months (range: 1-51 months). The three-year disease-free rate was 38.0% and the overall survival rate was 58.7%.
Petrosectomy is an effective treatment for malignant temporal bone invasion. The probability of a good outcome was statistically decreased with a high T grade, positive margins, and salvage surgery. Younger age is connected with better prognosis. One of the major tasks remains to improve detection and to shorten the time to diagnosis, keeping in mind that symptoms are insidious and in younger people, the time before diagnosis was longer.
介绍针对因特定原发性癌症导致颞骨侵犯患者进行广泛手术（外侧、次全、全岩骨切除术）的结果。
回顾性病例分析。
四个三级转诊中心。
2006年1月至2010年12月期间接受治疗的89例颞骨癌症患者。
多学科团队治疗方法，包括手术切除、重建及术后放疗。
疾病特异性生存率、总生存率。
27.0%的患者出现复发，平均复发时间为术后6.3个月；31例患者（34.8%）在随访期间死亡。平均死亡时间为22.1个月。54例患者（58.7%）在观察期内存活。平均生存时间为42.0个月。复发后生存的中位时间为12个月（范围：1 - 51个月）。三年无病生存率为38.0%，总生存率为58.7%。
岩骨切除术是治疗恶性颞骨侵犯的有效方法。高T分级、切缘阳性及挽救性手术会使良好预后的概率在统计学上降低。年轻患者预后较好。主要任务之一仍是改善检测并缩短诊断时间，要记住症状隐匿，且在年轻患者中，诊断前的时间更长。
