[2008年肾细胞癌。组织病理学、分子遗传学及新的治疗选择]

[Renal cell carcinoma 2008. Histopathology, molecular genetics and new therapeutic options].

作者信息

Hammerschmied C G, Walter B, Hartmann A

机构信息

Pathologisches Institut, Universitätsklinikum Erlangen, Krankenhausstrasse 12, 91054, Erlangen.

出版信息

Pathologe. 2008 Sep;29(5):354-63. doi: 10.1007/s00292-008-1011-5.

DOI:10.1007/s00292-008-1011-5

PMID:18592242

Abstract

By integrating genetic data into the traditional histology and immunohistochemistry-based classification system the revised WHO-classification of malignant tumours (2004) defined additional renal cell carcinoma subtypes, thereby enabling the application of additional diagnostic procedures. Therapy for advanced clear cell renal cell carcinoma has also seen significant progress. This report focuses on these developments, pinpoints current obstacles and provides future prospects.

摘要

通过将基因数据整合到传统的基于组织学和免疫组织化学的分类系统中，2004年修订的世界卫生组织恶性肿瘤分类定义了更多肾细胞癌亚型，从而使更多诊断程序得以应用。晚期透明细胞肾细胞癌的治疗也取得了显著进展。本报告重点关注这些进展，指出当前的障碍并提供未来前景。