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Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism.

作者信息

Medh R D, Gupta V, Awasthi Y C

机构信息

Mercy Hospital Regional Oncology Center; Department of Medicine, University of Pittsburgh, PA.

出版信息

Biochem Pharmacol. 1991 Jul 5;42(2):439-41. doi: 10.1016/0006-2952(91)90733-l.

DOI:10.1016/0006-2952(91)90733-l
PMID:1859455
Abstract
摘要

相似文献

1
Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism.通过调节谷胱甘肽代谢逆转体内外美法仑耐药性
Biochem Pharmacol. 1991 Jul 5;42(2):439-41. doi: 10.1016/0006-2952(91)90733-l.
2
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.丁硫氨酸亚砜胺介导的谷胱甘肽耗竭增强阿霉素、美法仑和顺铂对耐药及敏感人卵巢癌细胞系的细胞毒性。
Biochem Pharmacol. 1985 Jul 15;34(14):2583-6. doi: 10.1016/0006-2952(85)90551-9.
3
Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells.美法仑耐药人前列腺癌细胞中谷胱甘肽/谷胱甘肽-S-转移酶解毒系统的特征
J Urol. 1993 Jul;150(1):209-14. doi: 10.1016/s0022-5347(17)35448-4.
4
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.在具有细胞内谷胱甘肽和谷胱甘肽-S-转移酶活性升高的美法仑耐药性乳腺癌细胞中氮芥与DNA的相互作用。
Cancer Chemother Pharmacol. 1992;30(5):341-7. doi: 10.1007/BF00689960.
5
The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells.人卵巢肿瘤细胞中核谷胱甘肽水平与美法仑耐药性之间的关系。
Biochem Pharmacol. 1991 Feb 15;41(4):647-9. doi: 10.1016/0006-2952(91)90642-i.
6
Relationship between melanogenesis, glutathione levels and melphalan toxicity in human melanoma cells.人黑色素瘤细胞中黑色素生成、谷胱甘肽水平与美法仑毒性之间的关系
Melanoma Res. 1992 Dec;2(5-6):305-14. doi: 10.1097/00008390-199212000-00003.
7
Development and characterization of a melphalan-resistant human multiple myeloma cell line.
Cancer Res. 1991 Feb 1;51(3):995-1002.
8
Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard.丁硫氨酸亚砜胺降低细胞内谷胱甘肽水平及使小鼠肿瘤细胞对L-苯丙氨酸氮芥敏感化
Biochem Pharmacol. 1984 Feb 1;33(3):485-90. doi: 10.1016/0006-2952(84)90245-4.
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Changes in glutathione content and resistance to anticancer agents in human stomach cancer cells induced by treatments with melphalan in vitro.美法仑体外处理诱导人胃癌细胞谷胱甘肽含量变化及对抗癌剂的耐药性
Cancer Res. 1990 Jun 15;50(12):3614-8.
10
Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro.离散核谷胱甘肽池因氧化应激而非丁硫氨酸亚砜胺而耗竭。与体外增强的烷基化剂对人黑色素瘤细胞的细胞毒性相关。
Biochem Pharmacol. 1992 Oct 6;44(7):1383-93. doi: 10.1016/0006-2952(92)90540-y.

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Proteometabolomics of Melphalan Resistance in Multiple Myeloma.多发性骨髓瘤中美法仑耐药的蛋白质代谢组学
Methods Mol Biol. 2019;1996:273-296. doi: 10.1007/978-1-4939-9488-5_21.