人卵巢肿瘤细胞中核谷胱甘肽水平与美法仑耐药性之间的关系。 - Suppr

The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells.

作者信息

Britten R A, Green J A, Broughton C, Browning P G, White R, Warenius H M

机构信息

CRC Dept Radiation Oncology, University of Liverpool, J. K. Douglas Laboratories, Clatterbridge Hospital, Bebington, Wirral, U.K.

出版信息

Biochem Pharmacol. 1991 Feb 15;41(4):647-9. doi: 10.1016/0006-2952(91)90642-i.

DOI:10.1016/0006-2952(91)90642-i

PMID:1997012

Abstract

摘要

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The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells.人卵巢肿瘤细胞中核谷胱甘肽水平与美法仑耐药性之间的关系。

Biochem Pharmacol. 1991 Feb 15;41(4):647-9. doi: 10.1016/0006-2952(91)90642-i.

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.丁硫氨酸亚砜胺介导的谷胱甘肽耗竭增强阿霉素、美法仑和顺铂对耐药及敏感人卵巢癌细胞系的细胞毒性。

Biochem Pharmacol. 1985 Jul 15;34(14):2583-6. doi: 10.1016/0006-2952(85)90551-9.

Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard.丁硫氨酸亚砜胺降低细胞内谷胱甘肽水平及使小鼠肿瘤细胞对L-苯丙氨酸氮芥敏感化

Biochem Pharmacol. 1984 Feb 1;33(3):485-90. doi: 10.1016/0006-2952(84)90245-4.

Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer.人卵巢癌中的细胞谷胱甘肽水平以及对辐射和抗肿瘤药物的敏感性

Prog Clin Biol Res. 1988;276:287-93.

Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro.离散核谷胱甘肽池因氧化应激而非丁硫氨酸亚砜胺而耗竭。与体外增强的烷基化剂对人黑色素瘤细胞的细胞毒性相关。

Biochem Pharmacol. 1992 Oct 6;44(7):1383-93. doi: 10.1016/0006-2952(92)90540-y.

Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism.通过调节谷胱甘肽代谢逆转体内外美法仑耐药性

Biochem Pharmacol. 1991 Jul 5;42(2):439-41. doi: 10.1016/0006-2952(91)90733-l.

Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.通过消耗谷胱甘肽增强美法仑对人卵巢癌细胞系的细胞毒性。

Cancer Res. 1984 Nov;44(11):5427-31.

Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione.通过丁硫氨酸亚砜胺消耗谷胱甘肽增强美法仑在人卵巢癌体外模型及荷瘤裸鼠中的细胞毒性。

Biochem Pharmacol. 1987 Jan 1;36(1):147-53. doi: 10.1016/0006-2952(87)90392-3.

Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells.美法仑耐药人前列腺癌细胞中谷胱甘肽/谷胱甘肽-S-转移酶解毒系统的特征

J Urol. 1993 Jul;150(1):209-14. doi: 10.1016/s0022-5347(17)35448-4.

Overcoming tumor necrosis factor-alpha resistance of human renal and ovarian carcinoma cells by combination treatment with buthionine sulfoximine and tumor necrosis factor-alpha. Role of tumor necrosis factor-alpha mRNA down-regulation in tumor cell sensitization.通过丁硫氨酸亚砜胺与肿瘤坏死因子-α联合治疗克服人肾癌细胞和卵巢癌细胞对肿瘤坏死因子-α的耐药性。肿瘤坏死因子-α mRNA下调在肿瘤细胞致敏中的作用。

Cancer. 1994 Feb 1;73(3):730-7. doi: 10.1002/1097-0142(19940201)73:3<730::aid-cncr2820730338>3.0.co;2-x.

引用本文的文献

The FOXO signaling axis displays conjoined functions in redox homeostasis and stemness.FOXO 信号通路在氧化还原平衡和干细胞特性中具有共同的功能。

Free Radic Biol Med. 2021 Jun;169:224-237. doi: 10.1016/j.freeradbiomed.2021.04.022. Epub 2021 Apr 18.

Simultaneous quantitation of oxidized and reduced glutathione via LC-MS/MS: An insight into the redox state of hematopoietic stem cells.通过液相色谱-串联质谱法同时定量氧化型和还原型谷胱甘肽：深入了解造血干细胞的氧化还原状态。

Free Radic Biol Med. 2016 Aug;97:85-94. doi: 10.1016/j.freeradbiomed.2016.05.005. Epub 2016 May 19.

The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts.细胞核内谷胱甘肽的消耗会损害3T3成纤维细胞的增殖。

PLoS One. 2009 Jul 29;4(7):e6413. doi: 10.1371/journal.pone.0006413.

Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line.谷胱甘肽耗竭会增加美法仑对PC-3（一种雄激素不敏感的前列腺癌细胞系）的细胞毒性。

Cancer Chemother Pharmacol. 1993;32(1):73-7. doi: 10.1007/BF00685880.

Cytotoxicity of antitumor platinum complexes with L-buthionine-(R,S)-sulfoximine and/or etanidazole in human carcinoma cell lines sensitive and resistant to cisplatin.抗肿瘤铂配合物与L-丁硫氨酸-（R，S）-亚砜亚胺和/或乙磺硝唑在对顺铂敏感和耐药的人癌细胞系中的细胞毒性。

Cancer Chemother Pharmacol. 1995;36(5):431-8. doi: 10.1007/BF00686193.

Differential effects of depleting agents on cytoplasmic and nuclear non-protein sulphydryls: a fluorescence image cytometry study.耗竭剂对细胞质和细胞核非蛋白质巯基的不同作用：一项荧光图像细胞术研究。

Br J Cancer. 1995 Jul;72(1):45-50. doi: 10.1038/bjc.1995.275.

Demonstration of nuclear compartmentalization of glutathione in hepatocytes.肝细胞中谷胱甘肽核区室化的证明。

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4412-6. doi: 10.1073/pnas.89.10.4412.

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The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells.

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