双膦酸盐、颌骨坏死及牙科治疗建议

Bisphosphonates, osteonecrosis of the jaw, and dental treatment recommendations.

作者信息

Radfar Lida, Masood Farah

机构信息

Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, Oklahoma, USA.

出版信息

J Okla Dent Assoc. 2008 Apr-May;99(7):28-9.

PMID:18595621

Abstract

Millions of patients in the United States take bisphosphonates for management of malignant bone metastases, osteoporosis, osteitis deformans (Paget's disease), and osteogenesis imperfecta. Since 2003, over 200 cases of osteonecrosis of the jaws have been described, mostly in patients with multiple myeloma or breast cancer patients, and to a lesser extent in patients on oral medications.

摘要

在美国，数以百万计的患者服用双膦酸盐来治疗恶性骨转移、骨质疏松症、畸形性骨炎（佩吉特病）和成骨不全症。自2003年以来，已报道了200多例颌骨坏死病例，大多发生在多发性骨髓瘤患者或乳腺癌患者中，口服药物治疗的患者中出现此类病例的情况较少。