Davis Mollie M, King James C, Moag Lauren, Cummings Ginny, Magder Laurence S
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21205, USA.
Pediatrics. 2008 Jul;122(1):e260-5. doi: 10.1542/peds.2007-2963.
Live attenuated influenza vaccine was given to 5319 (44%) of the 12090 students enrolled in public elementary schools in Carroll County, Maryland, during the fall of 2005. We examined the impact of this community-based intervention on countywide student absenteeism during the subsequent influenza outbreak.
This study used existing, anonymous information: census data, community influenza tests, and public school absenteeism data. The intervention group was Carroll County, years 2005-2006. The control group included Carroll County, years 2001-2005, and adjacent Frederick County, years 2001-2006. Weekly student absenteeism was determined during baseline influenza-free periods and influenza outbreak periods for all of the public schools.
The absolute change in absenteeism during the influenza outbreak periods over baseline in elementary schools was 0.61% for the intervention group and 1.79% for the control group. Similarly, the change in absenteeism during the influenza outbreak period over baseline for high schools was 0.32% for the intervention group and 1.80% for the control group. Although not statistically significant, trends in middle schools were similar.
Countywide school-based influenza vaccination was associated with reduced absenteeism during an influenza outbreak. The data suggest not only a direct impact on elementary schools but also an indirect impact on high schools. School-based programs provide an efficient method of providing influenza vaccination to children, and protection may extend to unvaccinated community members. Additional research is needed to determine whether school-based vaccination of children reduces morbidity and mortality associated with influenza outbreaks.
2005年秋季,在马里兰州卡罗尔县公立小学入学的12090名学生中,有5319名(44%)接种了减毒活流感疫苗。我们研究了这种基于社区的干预措施对随后流感暴发期间全县学生缺勤率的影响。
本研究使用现有的匿名信息:人口普查数据、社区流感检测数据和公立学校缺勤数据。干预组为2005 - 2006年的卡罗尔县。对照组包括2001 - 2005年的卡罗尔县以及2001 - 2006年的相邻弗雷德里克县。在所有公立学校的基线无流感期和流感暴发期确定每周学生缺勤率。
小学流感暴发期缺勤率相对于基线的绝对变化,干预组为0.61%,对照组为1.79%。同样,高中流感暴发期缺勤率相对于基线的变化,干预组为0.32%,对照组为1.80%。虽然无统计学显著性,但初中的趋势相似。
全县范围内基于学校的流感疫苗接种与流感暴发期间缺勤率降低有关。数据表明不仅对小学有直接影响,对高中也有间接影响。基于学校的项目为儿童提供流感疫苗接种提供了一种有效方法,而且保护作用可能延伸至未接种疫苗的社区成员。需要进一步研究以确定儿童基于学校的疫苗接种是否能降低与流感暴发相关的发病率和死亡率。