Moss Alvin H, Ganjoo Jesse, Sharma Sanjay, Gansor Julie, Senft Sharon, Weaner Barbara, Dalton Cheryl, MacKay Karen, Pellegrino Beth, Anantharaman Priya, Schmidt Rebecca
Section of Nephrology, Department of Medicine, School of Medicine, West Virginia University, Morgantown, West Virginia 26506-9022, USA.
Clin J Am Soc Nephrol. 2008 Sep;3(5):1379-84. doi: 10.2215/CJN.00940208. Epub 2008 Jul 2.
Dialysis patients are increasingly characterized by older age, multiple comorbidities, and shortened life expectancy. This study investigated whether the "surprise" question, "Would I be surprised if this patient died in the next year?" identifies patients who are at high risk for early mortality.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This prospective cohort study of 147 patients in three hemodialysis dialysis units classified patients into "yes" and "no" groups on the basis of the "surprise" question response and tracked patient status (alive or dead) at 12 mo. Demographics, Charlson Comorbidity Index score, and Karnofsky Performance Status score were measured.
Initially, 34 (23%) patients were classified in the "no" group. Compared with the 113 patients in the "yes" group, the patients in the "no" group were older (72.5 +/- 12.8 versus 64.5 +/- 14.9), had a higher comorbidity score (7.1 +/- 2.3 versus 5.8 +/- 2.1), and had a lower performance status score (69.7 +/- 17.1 versus 81.6 +/- 15.8). At 12 mo, 22 (15%) patients had died; the mortality rate for the "no" group was 29.4% and for the "yes" group was 10.6%. The odds of dying within 1 yr for the patients in the "no" group were 3.5 times higher than for patients in the "yes" group, (odds ratio 3.507, 95% CI 1.356 to 9.067, P = 0.01).
The "surprise" question is effective in identifying sicker dialysis patients who have a high risk for early mortality and should receive priority for palliative care interventions.
透析患者的特点越来越表现为年龄较大、合并多种疾病且预期寿命缩短。本研究调查了“意外”问题,即“如果该患者在明年死亡,我会感到意外吗?”能否识别出早期死亡风险较高的患者。
设计、地点、参与者及测量方法:这项对三个血液透析单位的147例患者进行的前瞻性队列研究,根据“意外”问题的回答将患者分为“是”和“否”两组,并在12个月时跟踪患者状态(存活或死亡)。测量了人口统计学数据、查尔森合并症指数评分和卡诺夫斯基功能状态评分。
最初,34例(23%)患者被归类为“否”组。与“是”组的113例患者相比,“否”组患者年龄更大(72.5±12.8岁对64.5±14.9岁),合并症评分更高(7.1±2.3对5.8±2.1),功能状态评分更低(69.7±17.1对81.6±15.8)。在12个月时,22例(15%)患者死亡;“否”组死亡率为29.4%,“是”组为10.6%。“否”组患者在1年内死亡的几率比“是”组患者高3.5倍(优势比3.507,95%可信区间1.356至9.067,P = 0.01)。
“意外”问题能有效识别出病情较重、早期死亡风险较高且应优先接受姑息治疗干预的透析患者。