Gimenez Monica, Soria-Pastor Sara, Junque Carme, Caldu Xavier, Narberhaus Ana, Botet Francesc, Bargallo Nuria, Falcon Carles, Mercader Josep Maria
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona 08036, Spain.
Pediatr Res. 2008 Nov;64(5):572-7. doi: 10.1203/PDR.0b013e3181841eab.
Prematurity is associated with volumetric reductions in specific brain areas such as the hippocampus and with metabolic changes that can be detected by spectroscopy. Short echo time (35 ms) Proton magnetic resonance spectroscopy (1H MRS) was performed to assess possible medial temporal lobe metabolic abnormalities in 21 adolescents with preterm birth (mean age: 14.8, SD: 1.3) compared with an age-matched control sample (mean age: 14.8, SD: 1.6). 1H MRS spectra were analyzed with linear combination model fitting, obtaining the absolute metabolite concentrations for Creatine (Cr), and myo-inositol (Ins). In addition, the following metabolite sums were measured: total Cho (glycerophospho-choline + phosphocholine), total N-acetyl-aspartate + N-acetyl-aspartylglutamate (NA), and total Glx (glutamate + glutamine). A stereological analysis was performed to calculate hippocampal volume. Absolute Cr, and total NA values were decreased in the preterm group (p = 0.016; p = 0.002, respectively). The preterm also showed a hippocampal reduction (p < 0.0001). Significant relationships were found between gestational age and different metabolites and the hippocampal volume. Moreover, hippocampal volume correlated with brain metabolites in the whole sample. Results demonstrate that prematurity affects medial temporal lobe metabolites, and that the alteration is related to structural changes, suggesting that the cerebral changes persist until adolescence.
早产与特定脑区（如海马体）的体积减小以及可通过光谱学检测到的代谢变化有关。对21名早产青少年（平均年龄：14.8岁，标准差：1.3）进行了短回波时间（35毫秒）的质子磁共振波谱（1H MRS）检查，以评估内侧颞叶可能存在的代谢异常，并与年龄匹配的对照样本（平均年龄：14.8岁，标准差：1.6）进行比较。使用线性组合模型拟合分析1H MRS波谱，得出肌酸（Cr）和肌醇（Ins）的绝对代谢物浓度。此外，还测量了以下代谢物总和：总胆碱（甘油磷酸胆碱+磷酸胆碱）、总N-乙酰天门冬氨酸+N-乙酰天门冬氨酰谷氨酸（NA）以及总谷氨酰胺（谷氨酸+谷氨酰胺）。进行了体视学分析以计算海马体体积。早产组的绝对Cr和总NA值降低（分别为p = 0.016；p = 0.002）。早产组还显示出海马体体积减小（p < 0.0001）。在胎龄与不同代谢物以及海马体体积之间发现了显著相关性。此外，在整个样本中，海马体体积与脑代谢物相关。结果表明，早产会影响内侧颞叶代谢物，且这种改变与结构变化有关，这表明脑部变化会持续到青春期。
