Kroth Julia, Weidlich Kathrin, Hiedl Stephan, Nussbaum Claudia, Christ Frank, Genzel-boroviczény Orsolya
Clinic of Dermatology and Allerology, University of Munich, 80337 Munich, Germany.
Pediatr Res. 2008 Nov;64(5):567-71. doi: 10.1203/PDR.0b013e318184134e.
Changes in microcirculation have been recognized as central to many disease processes. The aim of this study was to evaluate factors, which influence the microcirculation of the skin during the first month of life in premature infants. Red blood cell (RBC) velocity, vessel diameter, and functional small vessel density (FSVD) were measured daily for the first 30 d on the upper arm in preterm infants with gestational age <30 wk. Orthogonal polarization spectral (OPS) images were analyzed off-line with the Capi- Scope-Image program. In 25 infants, FSVD decreased significantly from week 1 (mean +/- SD 236 +/- 33 cm/cm2) to week 4 (207 +/- 30 cm/cm2) and correlated directly with Hb levels and incubator temperature. Vessel diameters and RBC velocity did not change significantly, nor did clinical parameters such as blood pressure, heart rate or body temperature. Microvascular parameters were not dependent on gestational or postnatal age. The microcirculation of the skin might be an easily accessible window to obtain better understanding of circulatory changes in the postnatal period. Our data are essential as basis for further studies in this field. Hb levels and possible incubator temperatures have a substantial influence on functional small vessel density and therefore need to be taken in account.
微循环的变化已被认为是许多疾病过程的核心。本研究的目的是评估影响早产儿出生后第一个月皮肤微循环的因素。对胎龄<30周的早产儿，在出生后的前30天每天测量其上臂的红细胞（RBC）速度、血管直径和功能性小血管密度（FSVD）。使用Capi-Scope-Image程序对正交偏振光谱（OPS）图像进行离线分析。在25名婴儿中，FSVD从第1周（平均±标准差236±33 cm/cm²）到第4周（207±30 cm/cm²）显著下降，并且与血红蛋白水平和暖箱温度直接相关。血管直径和RBC速度没有显著变化，血压、心率或体温等临床参数也没有变化。微血管参数不依赖于胎龄或出生后年龄。皮肤微循环可能是一个易于观察的窗口，有助于更好地了解出生后时期的循环变化。我们的数据是该领域进一步研究的重要基础。血红蛋白水平和可能的暖箱温度对功能性小血管密度有重大影响，因此需要加以考虑。
