Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. anke.top @ addenbrookes.nhs.uk
Neonatology. 2011;99(1):73-7. doi: 10.1159/000316945. Epub 2010 Aug 24.
Changes in the microcirculation have been recognized to play a crucial role in many disease processes. In premature neonates, functional capillary density (FCD) decreases during the first months of life.
The aims of this study were to obtain microcirculatory parameters in term neonates and older children who did not present with compromised respiration or circulation and to determine developmental changes in the microcirculation in young children.
This single-center prospective observational study was performed at a level III university children's hospital. Subjects eligible for inclusion were children up to the age of 3 years who did not have any respiratory compromise, circulatory compromise or signs of dehydration. The buccal mucosa of 45 children was assessed, using orthogonal polarization spectral imaging.
We found a significantly higher FCD in neonates younger than 1 week compared with older children. The median FCD was 8.1 cm/cm(2) (range 7.3-9.4) for 0- to 7-day-old neonates (n = 12), 6.9 cm/cm(2) (range 4.7-8.7) for 8- to 28-day-olds (n = 10), 7.3 cm/cm(2) (range 6.1-8.8) for 1- to 6-month-olds (n = 19) and 6.7 cm/cm(2) (range 6.5-9.2) for 3-year-olds (n = 4). After the first week, there was no significant correlation between age and FCD.
FCD of the buccal mucosa decreases after the first week of life.
微循环的变化已被认为在许多疾病过程中起着至关重要的作用。在早产儿中，功能性毛细血管密度（FCD）在生命的头几个月内下降。
本研究的目的是获得无呼吸或循环功能障碍的足月新生儿和大龄儿童的微循环参数，并确定儿童期微循环的发育变化。
这是一项在三级大学儿童医院进行的单中心前瞻性观察性研究。符合纳入标准的受试者为年龄在 3 岁以下、无呼吸窘迫、循环功能障碍或脱水迹象的儿童。使用正交偏振光谱成像对 45 名儿童的颊黏膜进行评估。
我们发现，与大龄儿童相比，1 周龄以下的新生儿 FCD 显著更高。0-7 天龄新生儿的中位数 FCD 为 8.1cm/cm²（范围 7.3-9.4）（n=12），8-28 天龄新生儿为 6.9cm/cm²（范围 4.7-8.7）（n=10），1-6 月龄婴儿为 7.3cm/cm²（范围 6.1-8.8）（n=19），3 岁儿童为 6.7cm/cm²（范围 6.5-9.2）（n=4）。第一周后，年龄与 FCD 之间无显著相关性。
颊黏膜 FCD 在生命的第一周后下降。
