Marsh B, White M, Morton N, Kenny G N
Division of Anaesthetics, Glasgow Royal Infirmary.
Br J Anaesth. 1991 Jul;67(1):41-8. doi: 10.1093/bja/67.1.41.
A computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures. The device was programmed with an adult pharmacokinetic model for propofol. During and after anaesthesia, blood samples were taken for measurement of propofol concentrations and it was found that the values obtained were systematically overpredicted by the delivery system algorithm. New pharmacokinetic microconstants were derived from our data which reflected more accurately the elimination and distribution of propofol in a prospective study involving another 10 children.
一种用于丙泊酚的计算机控制输注装置被用于对20名接受小型外科手术的儿童进行全身麻醉诱导和维持。该装置采用了丙泊酚的成人药代动力学模型进行编程。在麻醉期间及之后，采集血样以测量丙泊酚浓度，结果发现输送系统算法系统性地高估了所获得的值。在前瞻性研究中，从我们的数据中得出了新的药代动力学微常数，该研究涉及另外10名儿童，这些微常数能更准确地反映丙泊酚的消除和分布情况。
