Ferrari Enrico, Stalder Nicolas, von Segesser Ludwig K
Department of Cardiovascular Surgery, University Hospital of Lausanne, Lausanne, Switzerland.
J Cardiothorac Surg. 2008 Jul 2;3:38. doi: 10.1186/1749-8090-3-38.
Cardiopulmonary bypass (CPB) with aortic cross-clamping and cardioplegic arrest remains the method of choice for patients requiring standard myocardial revascularization. Therefore, very high-risk patients presenting with acute coronary syndrome, unstable angina, onset of cardiac decompensation and requiring emergency multiple myocardial revascularization, can have a poor outcome. The on-pump beating heart technique can reduce the mortality and the morbidity in such a selected group of patients and this report describes our clinical experience.
Out of 290 patients operated for CABG from January 2005 to January 2006, 25 (8.6%) selected high-risk patients suffering from life threatening coronary syndrome (mean age 69 +/- 7 years) and requiring emergency multiple myocardial revascularization, underwent on-pump beating heart surgery. The mean pre-operative left ventricle ejection fraction (LVEF) was 27 +/- 8%. The majority of them (88%) suffered of tri-vessel coronary disease and 6 (24%) had a left main stump disease. Nine patients (35%) were on severe cardiac failure and seven among them (28%) received a pre-operative intra-aortic balloon pump. The pre-operative EuroScore rate was equal or above 8 in 18 patients (73%).
All patients underwent on-pump-beating heart coronary revascularization. The mean number of graft/patient was 2.9 +/- 0.6 and the internal mammary artery was used in 23 patients (92%). The mean CPB time was 84 +/- 19 minutes. Two patients died during the recovery stay in the intensive care unit, and there were no postoperative myocardial infarctions between the survivors. Eight patients suffered of transitorily renal failure and 1 patient developed a sternal wound infection. The mean hospital stay was 12 +/- 7 days. The follow-up was complete for all 23 patients survived at surgery and the mean follow-up time was 14 +/- 5 months. One patient died during the follow-up for cardiac arrest and 2 patients required an implantable cardiac defibrillator. One year after surgery they all had a standard trans-thoracic echocardiogram showing a mean LVEF rate of 36 +/- 11.8%.
Standard on-pump arrested heart coronary surgery has higher mortality and morbidity in emergencies. The on-pump beating heart myocardial revascularization seems to be a valid alternative for the restricted and selected cohort of patients suffering from life threatening coronary syndrome and requiring multiple emergency CABG.
对于需要进行标准心肌血运重建的患者,采用主动脉交叉钳夹和心脏停搏的体外循环(CPB)仍是首选方法。因此,患有急性冠状动脉综合征、不稳定型心绞痛、心脏失代偿发作且需要紧急进行多次心肌血运重建的极高危患者,预后可能较差。不停跳心脏技术可降低这类特定患者群体的死亡率和发病率,本报告描述了我们的临床经验。
在2005年1月至2006年1月接受冠状动脉旁路移植术(CABG)的290例患者中,25例(8.6%)选定的高危患者患有危及生命的冠状动脉综合征(平均年龄69±7岁),需要紧急进行多次心肌血运重建,接受了不停跳心脏手术。术前左心室射血分数(LVEF)平均为27±8%。其中大多数(88%)患有三支冠状动脉疾病,6例(24%)有左主干病变。9例患者(35%)处于严重心力衰竭状态,其中7例(28%)术前接受了主动脉内球囊反搏。18例患者(73%)术前欧洲心脏手术风险评估系统(EuroScore)评分等于或高于8分。
所有患者均接受了不停跳心脏冠状动脉血运重建术。平均每位患者的移植血管数为2.9±0.6,23例患者(92%)使用了乳内动脉。平均CPB时间为84±19分钟。2例患者在重症监护病房恢复期间死亡,幸存者中无术后心肌梗死发生。8例患者出现短暂性肾衰竭,1例患者发生胸骨伤口感染。平均住院时间为12±7天。对手术存活的所有23例患者进行了完整随访,平均随访时间为14±5个月。1例患者在随访期间因心脏骤停死亡,2例患者需要植入心脏除颤器。术后一年,他们均进行了标准的经胸超声心动图检查,显示平均LVEF率为36±11.8%。
在紧急情况下,标准的停跳心脏冠状动脉手术死亡率和发病率较高。对于患有危及生命的冠状动脉综合征且需要多次紧急CABG的受限特定患者群体,不停跳心脏心肌血运重建似乎是一种有效的替代方法。