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用于需要急诊进行多次冠状动脉搭桥术的高危患者的体外循环下不停跳冠状动脉手术。

On-pump beating heart coronary surgery for high risk patients requiring emergency multiple coronary artery bypass grafting.

作者信息

Ferrari Enrico, Stalder Nicolas, von Segesser Ludwig K

机构信息

Department of Cardiovascular Surgery, University Hospital of Lausanne, Lausanne, Switzerland.

出版信息

J Cardiothorac Surg. 2008 Jul 2;3:38. doi: 10.1186/1749-8090-3-38.

Abstract

BACKGROUND

Cardiopulmonary bypass (CPB) with aortic cross-clamping and cardioplegic arrest remains the method of choice for patients requiring standard myocardial revascularization. Therefore, very high-risk patients presenting with acute coronary syndrome, unstable angina, onset of cardiac decompensation and requiring emergency multiple myocardial revascularization, can have a poor outcome. The on-pump beating heart technique can reduce the mortality and the morbidity in such a selected group of patients and this report describes our clinical experience.

METHODS

Out of 290 patients operated for CABG from January 2005 to January 2006, 25 (8.6%) selected high-risk patients suffering from life threatening coronary syndrome (mean age 69 +/- 7 years) and requiring emergency multiple myocardial revascularization, underwent on-pump beating heart surgery. The mean pre-operative left ventricle ejection fraction (LVEF) was 27 +/- 8%. The majority of them (88%) suffered of tri-vessel coronary disease and 6 (24%) had a left main stump disease. Nine patients (35%) were on severe cardiac failure and seven among them (28%) received a pre-operative intra-aortic balloon pump. The pre-operative EuroScore rate was equal or above 8 in 18 patients (73%).

RESULTS

All patients underwent on-pump-beating heart coronary revascularization. The mean number of graft/patient was 2.9 +/- 0.6 and the internal mammary artery was used in 23 patients (92%). The mean CPB time was 84 +/- 19 minutes. Two patients died during the recovery stay in the intensive care unit, and there were no postoperative myocardial infarctions between the survivors. Eight patients suffered of transitorily renal failure and 1 patient developed a sternal wound infection. The mean hospital stay was 12 +/- 7 days. The follow-up was complete for all 23 patients survived at surgery and the mean follow-up time was 14 +/- 5 months. One patient died during the follow-up for cardiac arrest and 2 patients required an implantable cardiac defibrillator. One year after surgery they all had a standard trans-thoracic echocardiogram showing a mean LVEF rate of 36 +/- 11.8%.

CONCLUSION

Standard on-pump arrested heart coronary surgery has higher mortality and morbidity in emergencies. The on-pump beating heart myocardial revascularization seems to be a valid alternative for the restricted and selected cohort of patients suffering from life threatening coronary syndrome and requiring multiple emergency CABG.

摘要

背景

对于需要进行标准心肌血运重建的患者,采用主动脉交叉钳夹和心脏停搏的体外循环(CPB)仍是首选方法。因此,患有急性冠状动脉综合征、不稳定型心绞痛、心脏失代偿发作且需要紧急进行多次心肌血运重建的极高危患者,预后可能较差。不停跳心脏技术可降低这类特定患者群体的死亡率和发病率,本报告描述了我们的临床经验。

方法

在2005年1月至2006年1月接受冠状动脉旁路移植术(CABG)的290例患者中,25例(8.6%)选定的高危患者患有危及生命的冠状动脉综合征(平均年龄69±7岁),需要紧急进行多次心肌血运重建,接受了不停跳心脏手术。术前左心室射血分数(LVEF)平均为27±8%。其中大多数(88%)患有三支冠状动脉疾病,6例(24%)有左主干病变。9例患者(35%)处于严重心力衰竭状态,其中7例(28%)术前接受了主动脉内球囊反搏。18例患者(73%)术前欧洲心脏手术风险评估系统(EuroScore)评分等于或高于8分。

结果

所有患者均接受了不停跳心脏冠状动脉血运重建术。平均每位患者的移植血管数为2.9±0.6,23例患者(92%)使用了乳内动脉。平均CPB时间为84±19分钟。2例患者在重症监护病房恢复期间死亡,幸存者中无术后心肌梗死发生。8例患者出现短暂性肾衰竭,1例患者发生胸骨伤口感染。平均住院时间为12±7天。对手术存活的所有23例患者进行了完整随访,平均随访时间为14±5个月。1例患者在随访期间因心脏骤停死亡,2例患者需要植入心脏除颤器。术后一年,他们均进行了标准的经胸超声心动图检查,显示平均LVEF率为36±11.8%。

结论

在紧急情况下,标准的停跳心脏冠状动脉手术死亡率和发病率较高。对于患有危及生命的冠状动脉综合征且需要多次紧急CABG的受限特定患者群体,不停跳心脏心肌血运重建似乎是一种有效的替代方法。

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