[Central nervous system involvement in Wegener's granulomatosis].

作者信息

Jouret F, Noirhomme S, Grandin C, Lonneux M, Godfraind C, Lambert M, Lefebvre C

机构信息

Service de médecine interne générale, cliniques universitaires de Saint-Luc, université catholique Louvain, avenue Hippocrate, 1200 Bruxelles, Belgique.

出版信息

Rev Med Interne. 2008 Nov;29(11):912-6. doi: 10.1016/j.revmed.2008.04.003. Epub 2008 Jul 2.

DOI:10.1016/j.revmed.2008.04.003

PMID:18599161

Abstract

INTRODUCTION

Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis associated with c-ANCA antibodies. The involvement of the central nervous system in WG is uncommon and usually caused by in situ vasculitis, intracranial granuloma formation or contiguous invasion from extracranial sites.

CASE REPORT

Here, we report on a tumour-like expansion of a severe nasosinusal WG into the brain, which was confirmed by brain biopsy examination.

CONCLUSION

The positivity of positron emission tomography in our observation supports the potential role of such functional imaging in the staging, as well as in the follow-up of WG.

摘要