“显性”甲状腺肿大中肿瘤形成及恶变的风险
Risk of neoplasia and malignancy in "dominant" thyroid swellings.
作者信息
Cusick E L, Krukowski Z H, MacIntosh C A, Matheson N A
机构信息
Department of Surgery, University of Aberdeen.
出版信息
BMJ. 1991 Jul 6;303(6793):20-2. doi: 10.1136/bmj.303.6793.20.
OBJECTIVE
To determine the risk of neoplasia and malignancy in "dominant" thyroid swellings.
DESIGN
Prospective analysis during six years.
SETTING
Thyroid clinic serving the Grampian region.
PATIENTS
574 consecutive patients presenting with a discrete thyroid swelling, of whom 179 (31%) were classified clinically as having a dominant area of enlargement within a multinodular gland.
RESULTS
After clinical and cytological assessment 77 dominant swellings were excised. Of the excised swellings, 45 were non-neoplastic and 32 neoplastic, including 11 malignant lesions. The minimum incidence of neoplasia and malignancy in all 179 dominant swellings was therefore 18% and 6% respectively.
CONCLUSION
Dominant thyroid swellings should be regarded with greater clinical suspicion than has been traditional.
目的
确定“优势性”甲状腺肿大发生肿瘤和恶性病变的风险。
设计
为期六年的前瞻性分析。
地点
服务于格兰扁地区的甲状腺诊所。
患者
574例连续出现孤立性甲状腺肿大的患者，其中179例（31%）临床分类为多结节性腺体中有一个优势性肿大区域。
结果
经过临床和细胞学评估后，77个优势性肿大被切除。在切除的肿大中，45个为非肿瘤性，32个为肿瘤性，其中包括11个恶性病变。因此，在所有179个优势性肿大中，肿瘤和恶性病变的最低发生率分别为18%和6%。
结论
相对于传统认识，优势性甲状腺肿大应受到更大的临床怀疑。
Zotero 插件