Driver Jane A, Smith Ashley, Buring Julie E, Gaziano J Michael, Kurth Tobias, Logroscino Giancarlo
Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Diabetes Care. 2008 Oct;31(10):2003-5. doi: 10.2337/dc08-0688. Epub 2008 Jul 3.
To evaluate the association between type 2 diabetes and newly reported Parkinson's disease.
Our study included 21,841 participants in the Physicians' Health Study, a cohort of U.S. male physicians. Diabetes and Parkinson's disease were self-reported via questionnaire. We used time-varying Cox regression to calculate adjusted relative risk (RR) for Parkinson's disease.
Over 23 years, 556 individuals with Parkinson's disease were identified. Subjects with diabetes had an increased Parkinson's disease risk (multivariable-adjusted RR 1.34 [95% CI 1.01-1.77]). The association remained significant after exclusion of those with known vascular disease. The diagnosis of diabetes was clustered around the diagnosis of Parkinson's disease and was more apparent among men with short diabetes duration and those without complications from diabetes.
Results of this large prospective study in men do not suggest that diabetes is a preceding risk factor for Parkinson's disease. Whether the positive association may be explained by ascertainment bias or a common underlying biological mechanism remains to be established.
评估2型糖尿病与新诊断的帕金森病之间的关联。
我们的研究纳入了美国男性医生队列“医师健康研究”中的21841名参与者。糖尿病和帕金森病通过问卷调查自我报告。我们使用时变Cox回归计算帕金森病的调整相对风险（RR）。
在23年的时间里，共识别出556例帕金森病患者。糖尿病患者患帕金森病的风险增加（多变量调整RR为1.34 [95% CI 1.01 - 1.77]）。排除已知患有血管疾病的患者后，这种关联仍然显著。糖尿病的诊断集中在帕金森病诊断前后，在糖尿病病程较短且无糖尿病并发症的男性中更为明显。
这项针对男性的大型前瞻性研究结果并不表明糖尿病是帕金森病的前驱危险因素。这种正相关关系是由确诊偏倚还是共同的潜在生物学机制所解释，仍有待确定。
