Yang Zhikuan, Lan Weizhong, Liu Wen, Chen Xiang, Nie Haohui, Yu Minbin, Ge Jian
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4779-83. doi: 10.1167/iovs.07-1616. Epub 2008 Jul 3.
To investigate the effect of ocular dominance on myopia development.
One hundred seventy-eight myopic children (age range, 7-13 years) were recruited for a 2-year longitudinal study. The development of myopia was evaluated by the change of objective refractive error, determined with cycloplegic autorefraction, and axial length, determined with A-scan ultrasonography. Ocular dominance was determined with the hole-in-the-card test. The change in refractive error and axial length between dominant and nondominant eyes were compared by using the paired t-test.
Twenty-nine subjects were lost to follow-up, and 19 reported poor compliance of wearing spectacles. The mean age of the retained 130 subjects was 10.9 +/- 1.6 years on entry. Sixty-nine (53.1%) subjects were boys. The mean refractive error of the two eyes was -1.73 +/- 0.69 D in spherical equivalent refractive error (SE) and the average anisometropia was 0.22 +/- 0.19 D. The percentages of right dominance, left dominance, and alternating ocular dominance were 64.6%, 34.6%, and 0.8%, respectively. After a 2-year follow-up, the mean change in SE was -1.34 +/- 0.59 and -1.33 +/- 0.64 D in the dominant and nondominant eye, respectively (P = 0.72). The mean increase in axial length was 0.67 +/- 0.42 and 0.64 +/- 0.37 mm, respectively (P = 0.48).
The findings demonstrated no statistically significant effect of ocular dominance on the development of myopia over a 2-year period. There was no sufficient evidence to support the idea that bias is introduced into myopia intervention clinical trials when myopia progression is evaluated without consideration of potential effects of ocular dominance on refractive development.
研究眼优势对近视发展的影响。
招募178名近视儿童（年龄范围为7至13岁）进行为期2年的纵向研究。通过睫状肌麻痹自动验光确定的客观屈光不正变化以及A超超声检查确定的眼轴长度来评估近视的发展。使用卡片孔测试确定眼优势。通过配对t检验比较优势眼和非优势眼之间屈光不正和眼轴长度的变化。
29名受试者失访，19名报告眼镜佩戴依从性差。入选的130名受试者的平均年龄为10.9±1.6岁。69名（53.1%）受试者为男孩。双眼的平均屈光不正为等效球镜度（SE）-1.73±0.69D，平均屈光参差为0.22±0.19D。右眼优势、左眼优势和交替性眼优势的比例分别为64.6%、34.6%和0.8%。经过2年随访，优势眼和非优势眼的SE平均变化分别为-1.34±0.59和-1.33±0.64D（P = 0.72）。眼轴长度的平均增加分别为0.67±0.42和0.64±0.37mm（P = 0.48）。
研究结果表明，在2年期间，眼优势对近视发展没有统计学上的显著影响。没有足够的证据支持以下观点：在评估近视进展时，如果不考虑眼优势对屈光发育的潜在影响，会在近视干预临床试验中引入偏差。
