Chin J H, Abas H Hj, Sabariah I
School of Pharmacy, University College Sedaya International, 56000 Kuala Lumpur, Malaysia.
Trop Biomed. 2008 Apr;25(1):9-16.
Orthosiphon stamineus Benth (Family: Lamiaceae) or locally known as Misai Kucing has been widely used in Malaysia for treating kidney problems, gout, and diabetes. This study aims to evaluate the possible toxic effect after following fourteen days oral administration of methanol extract of O. stamineus in female Sprague Dawley (SD) rats. Control groups were treated orally with distilled water (vehicle) while the four test groups were treated up to fourteen days with 0.5 g/kg, 1 g/kg, 3 g/kg and 5 g/kg body weight of methanol extract of O. stamineus respectively. Toxicity of the methanol extract of O. stamineus was evaluated by the incident of lethality, side-cage observation and blood serum biochemical parameters. No lethality or adverse toxic signs were seen during the experimental period. A significant decrease in several serum biochemical parameters i.e. AST and ALT and increase in liver weight was observed in young female SD rat after being fed fourteen days with methanol extract of O. stamineus. No delayed toxic effect and lethality was observed in all rats during fourteen days of recovery period. In conclusion, methanol extract of O. stamineus within these range and treatment duration would not cause any severe toxic effects and organ damages in rats.
猫须草（唇形科），当地称为肾茶，在马来西亚已被广泛用于治疗肾脏问题、痛风和糖尿病。本研究旨在评估雌性斯普拉格-道利（SD）大鼠口服猫须草甲醇提取物14天后可能产生的毒性作用。对照组口服蒸馏水（赋形剂），而四个试验组分别以0.5 g/kg、1 g/kg、3 g/kg和5 g/kg体重的猫须草甲醇提取物处理14天。通过致死率、笼边观察和血清生化参数评估猫须草甲醇提取物的毒性。实验期间未观察到致死或不良毒性迹象。在年轻雌性SD大鼠中，喂食猫须草甲醇提取物14天后，观察到几种血清生化参数即谷草转氨酶（AST）和谷丙转氨酶（ALT）显著降低，肝脏重量增加。在14天的恢复期内，所有大鼠均未观察到延迟毒性作用和致死情况。总之，在此剂量范围和治疗持续时间内，猫须草甲醇提取物不会对大鼠造成任何严重毒性作用和器官损伤。
