Lokman Ezarul Faradianna, Saparuddin Fatin, Muhammad Hussin, Omar Maizatul Hasyima, Zulkapli Azlina
Endocrine and Metabolic Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), Malaysia.
Institute for Medical Research, Ministry of Health Malaysia, Blok C7, NIH Complex, No. 1, Jalan Setia Murni U13/52, Seksyen U13, 40170 Setia Alam, Selangor, Malaysia.
Integr Med Res. 2019 Sep;8(3):173-179. doi: 10.1016/j.imr.2019.05.006. Epub 2019 Jun 5.
Maternal hyperglycemia is associated with increased risk of adverse outcomes for both mother and offspring. Insulin is the standard treatment of hyperglycemia with the aim to reduce risks of complications, however, due to several restrictions, the search for more effective drugs from traditional medicinal plants continues.
The antidiabetic effects of ( in non-pregnant and pregnant streptozotocin-induced Sprague Dawley rats were identified. The effect of different concentrations of on insulin level using isolated pancreatic islets in response to low and high concentrations of glucose was identified. Oral glucose tolerance test was performed in both pregnant and non-pregnant rats prior to and after treatment with (0.1 g/100 g of body weight). was given orally daily for 2 weeks in non-pregnant and 10 days in pregnant rats.
Oral glucose tolerance test indicated that treatment with in non-pregnant and pregnant rats significantly reduced blood glucose level and stimulated glucose-induced insulin secretion. No mortality was recorded throughout the study and no signs of toxicity during the experimental period including in both mother and foetus. For plasma analysis, the interactions of peptides such as GLP-1 and ghrelin level might contribute to the glucose lowering effect by via stimulation of insulin. The incubation of islets showed that significantly stimulated insulin release in response to high glucose.
could be a potential source of a specific oral hypoglycaemic agent to treat glucose intolerance in pregnancy.
母体高血糖与母亲和后代不良结局风险增加相关。胰岛素是高血糖的标准治疗药物，旨在降低并发症风险，然而，由于若干限制，对传统药用植物中更有效药物的探索仍在继续。
确定了（此处原文缺失具体药物名称）对非妊娠和妊娠链脲佐菌素诱导的斯普拉格-道利大鼠的抗糖尿病作用。使用分离的胰岛确定了不同浓度的（此处原文缺失具体药物名称）对低浓度和高浓度葡萄糖反应时胰岛素水平的影响。在妊娠和非妊娠大鼠用（此处原文缺失具体药物名称）（0.1 g/100 g体重）治疗前后进行口服葡萄糖耐量试验。非妊娠大鼠每日口服给药2周，妊娠大鼠口服给药10天。
口服葡萄糖耐量试验表明，在非妊娠和妊娠大鼠中用（此处原文缺失具体药物名称）治疗可显著降低血糖水平并刺激葡萄糖诱导的胰岛素分泌。在整个研究过程中未记录到死亡情况，在实验期间包括母体和胎儿均未出现毒性迹象。对于血浆分析，肽如胰高血糖素样肽-1和胃饥饿素水平的相互作用可能通过刺激胰岛素而有助于（此处原文缺失具体药物名称）的降糖作用。胰岛孵育显示，（此处原文缺失具体药物名称）在高葡萄糖刺激下显著刺激胰岛素释放。
（此处原文缺失具体药物名称）可能是治疗妊娠糖耐量异常的特定口服降糖药的潜在来源。
