Abdullah Noor Rain, Ismail Zakiah, Ismail Zhari
Herbal Medicine Research Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia.
Phytomedicine. 2009 Mar;16(2-3):222-6. doi: 10.1016/j.phymed.2007.04.013. Epub 2007 May 10.
The acute toxicity of standardized extract of Orthosiphon stamineus was studied in Sprague Dawley rats. The rats were administered a single dose of 5000 mg/kg body weight (BW) orally on Day 0 and observed for 14 days. There were no deaths recorded and the animals did not show signs of toxicity during the experimental period. The effect of the extract on general behavior, BW, food and water intake, relative organ weight per 100 g BW, hematology and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control. The acute toxicity LD(50) was estimated to be > 5000 mg/kg BW.
在斯普拉格-道利大鼠中研究了猫须草标准化提取物的急性毒性。在第0天给大鼠口服单剂量5000毫克/千克体重，并观察14天。实验期间无死亡记录，动物也未表现出毒性迹象。测量了提取物对一般行为、体重、食物和水摄入量、每100克体重的相对器官重量、血液学和临床生物化学的影响。与对照组相比，所有测量参数均未受影响。估计急性毒性半数致死量（LD50）>5000毫克/千克体重。
