Endou Hitoshi, Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan.
Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):578-84. doi: 10.1080/15257770802136024.
Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.
自从肾顶端尿酸/阴离子交换体URAT1（SLC22A12）的分子克隆以来，已鉴定出几种与尿酸转运相关的膜蛋白。此外，PDZ（PSD-95、DglA和ZO-1）结构域蛋白PDZK1作为URAT1的结合伴侣被鉴定出来，并且PDZ支架对肾顶端转运体的新作用导致了肾尿酸转运的新概念：尿酸转运多分子复合物，即“尿酸转运体”，它可能在肾近端小管的顶端膜形成最终的功能单位。阐明尿酸转运体将导致针对高尿酸血症的新药开发。
