Norsk Hydro A/S Technical Department, Porsgrunn, Norway.
Biotechnol Bioeng. 1992 Jan 20;39(2):186-94. doi: 10.1002/bit.260390210.
The rate of diffusion of serum albumin (MW 6.9 x 10(4) D) out of beads of calcium alginate gels depends upon the concentration and uronic acid composition of the alginate (ManA/GulA ratio), the conditions under which the beads are produced, the pH, and the temperature. The diffusion coefficient decreases with increasing alginate concentration, and (ManA/GulA) ratio and with decreasing pH. Diffusion out of the beads, in which the alginate is uniformly distributed (homogeneous gel), is faster than out of the beads in which the alginate is concentrated at the surface (inhomogeneous gel). The temperature dependence of the diffusion coefficient follows the Arrhenius law, with an activation energy of approximately 23 kJ x mol(-1).
血清白蛋白（MW 6.9 x 10(4) D）从钙藻酸盐凝胶珠中扩散的速率取决于藻酸盐的浓度和糖醛酸组成（ManA/GulA 比）、珠粒生产的条件、pH 值和温度。扩散系数随藻酸盐浓度、（ManA/GulA）比的增加和 pH 值的降低而降低。在藻酸盐均匀分布的珠粒（均匀凝胶）中扩散出珠粒比在藻酸盐集中在表面的珠粒（非均匀凝胶）中扩散出珠粒更快。扩散系数的温度依赖性遵循阿仑尼乌斯定律，其活化能约为 23 kJ x mol(-1)。
