Bilau Maaike, De Henauw Stefaan, Schroijen Carmen, Bruckers Liesbeth, Hond Elly Den, Koppen Gudrun, Matthys Christophe, Van De Mieroop Els, Keune Hans, Baeyens Willy, Nelen Vera, Van Larebeke Nik, Willems Jan L, Schoeters Greet
Department of Public Health, Ghent University, UZ 2 Blok A, De Pintelaan 185, B-9000 Ghent, Belgium.
Environ Int. 2009 Jan;35(1):9-13. doi: 10.1016/j.envint.2008.05.007. Epub 2008 Jul 3.
Dioxin-like activity was measured in the serum of 1425 Flemish men and women via the CALUX assay. The adults, aged between 50 and 65 years, participated in a large biomonitoring program, executed by the Flemish Center of Expertise for Environment and Health between 2002 and 2006. Within the context of this biomonitoring program also dietary intake of dioxin-like contaminants was assessed through a food frequency questionnaire. The relation between the estimated dietary intake and the dioxin-like activity in serum was evaluated using multivariate analyses: a logistic model was performed on the total population, while a linear regression analysis was done on the subsample with quantifiable dioxin activity levels in serum. Region, gender, age, BMI, smoking status, as well as dietary habits were entered in the model, with dioxin level as an outcome estimate. Both the logistic and linear model confirmed the contribution of dietary intake to the dioxin activity measured in serum. Also BMI and region were found to be associated with dioxin activity levels.
通过CALUX分析法测定了1425名弗拉芒男女血清中的二噁英样活性。这些成年人年龄在50至65岁之间，参与了由弗拉芒环境与健康专业中心在2002年至2006年期间开展的一项大型生物监测项目。在该生物监测项目中，还通过食物频率问卷评估了二噁英样污染物的膳食摄入量。使用多变量分析评估了估计的膳食摄入量与血清中二噁英样活性之间的关系：对总体人群进行了逻辑模型分析，而对血清中二噁英活性水平可量化的子样本进行了线性回归分析。将地区、性别、年龄、体重指数、吸烟状况以及饮食习惯纳入模型，以二噁英水平作为结果估计值。逻辑模型和线性模型均证实了膳食摄入量对血清中测得的二噁英活性的影响。还发现体重指数和地区与二噁英活性水平有关。
