Beswick Samantha, Affleck Paul, Elliott Faye, Gerry Edwina, Boon Andy, Bale Linda, Nolan Clarissa, Barrett Jennifer H, Bertram Chandra, Marsden Jerry, Bishop D Timothy, Newton-Bishop Julia A
Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital, Leeds, United Kingdom.
Eur J Cancer. 2008 Aug;44(12):1717-25. doi: 10.1016/j.ejca.2008.05.007. Epub 2008 Jul 2.
To identify lifestyle factors affecting risk of relapse.
A comparison of 131 relapsed melanoma patients with 147 non-relapsers.
Relapsers were more likely to report financial hardship using a number of different measures including access to holidays and feeling financially insecure (odds ratio (OR) 5.7, 95% confidence interval (CI) (1.5, 21.4)). Relapsers worked longer hours (mean 37h per week compared with 31, p=0.02). There was no reported difference in stress associated with recent life events. There was no effect of housing quality, employment factors or body mass index (BMI) on risk of relapse. There was a protective effect of antibiotics in the peri-operative period.
The study provides preliminary evidence for adverse effects of chronic financial hardship, but not recent stressful events on cancer relapse. As these data were collected in a retrospective case-control study subject to recall bias, the data must now be explored in a prospective study.
确定影响复发风险的生活方式因素。
对131例复发性黑色素瘤患者和147例未复发患者进行比较。
复发患者更有可能报告经济困难，采用了多种不同的衡量标准，包括度假机会和经济不安全感（优势比（OR）5.7，95%置信区间（CI）（1.5，21.4））。复发患者工作时间更长（平均每周37小时，而未复发患者为31小时，p = 0.02）。未报告近期生活事件相关压力存在差异。住房质量、就业因素或体重指数（BMI）对复发风险无影响。围手术期使用抗生素有保护作用。
该研究为慢性经济困难而非近期应激事件对癌症复发的不良影响提供了初步证据。由于这些数据是在一项受回忆偏倚影响的回顾性病例对照研究中收集的，现在必须在前瞻性研究中对这些数据进行探讨。
