Bernhard J-C, Ferriere J-M, Crepel M, Wallerand H, Bellec L, Lacroix B, Lopes D, Albouy B, Robert G, Ravaud A, Colombel M, Tostain J, Pfister C, Soulie M, Salomon L, De La Taille A, Pasticier G, Abbou C C, Manunta A, Guille F, Patard J-J
Service d'Urologie et Transplantation Rénale, CHU de Bordeaux, Place Amélie-Raba-Léon, Bordeaux Cedex, France.
Prog Urol. 2008 Jul;18(7):428-34. doi: 10.1016/j.purol.2008.04.012. Epub 2008 Jun 2.
To describe the practice of partial nephrectomy (PN) in France and assess its results in terms of morbidity and cancer control.
Seven French University Hospitals in which nephron sparing surgery represents at least 30% of the total number of nephrectomies for renal tumour, participated in this study. All centres included, as exhaustively as possible, all their PN cases. For each patient, 70 variables were harvested in order to characterize the patient population, the indications, the operative technique, the per- and postoperative course and complications, the tumor specificities, the carcinologic control and renal function follow-up.
Seven hundred and forty-one PN, of which 579 for malignant tumours were analysed. The mean tumour size was 3.4+/-2.1 cm (0.1-18) and 20.8% of the tumours were larger than 4 cm. In 30.1% of cases, the indication was imperative. Among the PN, 12.2% were performed laparoscopically. The mean operating time was 151+/-54.2 min (55-420). The medical and surgical complications rates were respectively 15.2 and 14.7%. At a mean 38 months follow-up, the local recurrence rate was 3.5% and the specific death rate was 4.5%.
PN is nowadays getting a more and more widely used technique in France. This expansion is completely justified by its results and urologists must consider nephron sparing surgery as the gold standard treatment for renal tumours measuring less than 4 cm.
描述法国部分肾切除术(PN)的实施情况,并评估其在发病率和癌症控制方面的结果。
七家法国大学医院参与了本研究,在这些医院中,保留肾单位手术占肾肿瘤肾切除术总数的至少30%。所有纳入的中心尽可能详尽地纳入了所有PN病例。为每位患者收集了70个变量,以描述患者群体、手术指征、手术技术、围手术期和术后过程及并发症、肿瘤特异性、癌症控制情况和肾功能随访情况。
共分析了741例PN,其中579例为恶性肿瘤。肿瘤平均大小为3.4±2.1 cm(0.1 - 18 cm),20.8%的肿瘤大于4 cm。在30.1%的病例中,手术指征是必须的。在PN中,12.2%是通过腹腔镜进行的。平均手术时间为151±54.2分钟(55 - 420分钟)。医疗和手术并发症发生率分别为15.2%和14.7%。平均随访38个月时,局部复发率为3.5%,特异性死亡率为4.5%。
如今,PN在法国是一种应用越来越广泛的技术。其结果完全证明了这种技术应用范围的扩大是合理的,泌尿外科医生必须将保留肾单位手术视为直径小于4 cm肾肿瘤的金标准治疗方法。