来自寄生线虫的巨噬细胞迁移抑制因子的直系同源物。
Orthologs of macrophage migration inhibitory factor from parasitic nematodes.
作者信息
Vermeire Jon J, Cho Yoonsang, Lolis Elias, Bucala Richard, Cappello Michael
机构信息
Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Trends Parasitol. 2008 Aug;24(8):355-63. doi: 10.1016/j.pt.2008.04.007. Epub 2008 Jul 4.
Abstract
Chronic helminth infections are associated with modulation of host cellular immune responses, presumably to prolong parasite survival within the mammalian host. This phenomenon is attributed, at least in part, to the elaboration of parasite molecules, including orthologs of host cytokines and receptors, at the host-parasite interface. This review describes recent progress in the characterization of macrophage migration inhibitory factor (MIF) orthologs from parasitic nematodes. The roles of these molecules in parasite developmental biology and pathogenesis are discussed. Further knowledge of the species-specific activities and three-dimensional structures of human and parasitic nematode MIF molecules should make them ideal targets for drug- and/or vaccine-based strategies aimed at nematode disease control.
摘要
慢性蠕虫感染与宿主细胞免疫反应的调节有关，推测这是为了延长寄生虫在哺乳动物宿主体内的存活时间。这种现象至少部分归因于寄生虫分子在宿主-寄生虫界面的产生，包括宿主细胞因子和受体的直系同源物。本综述描述了从寄生线虫中鉴定巨噬细胞迁移抑制因子（MIF）直系同源物的最新进展。讨论了这些分子在寄生虫发育生物学和发病机制中的作用。对人和寄生线虫MIF分子的物种特异性活性和三维结构的进一步了解，应使其成为基于药物和/或疫苗的线虫疾病控制策略的理想靶点。
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