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The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia.

作者信息

Kondo Takeshi, Mori Akio, Darmanin Stephanie, Hashino Satoshi, Tanaka Junji, Asaka Masahiro

出版信息

Haematologica. 2008 Sep;93(9):1414-6. doi: 10.3324/haematol.12854. Epub 2008 Jul 4.

DOI:10.3324/haematol.12854
PMID:18603554
Abstract
摘要

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1
The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia.第七种致病性融合基因FIP1L1-RARA是从t(4;17)阳性急性早幼粒细胞白血病中分离出来的。
Haematologica. 2008 Sep;93(9):1414-6. doi: 10.3324/haematol.12854. Epub 2008 Jul 4.
2
Acute promyelocytic leukemia harboring a STAT5B-RARA fusion gene and a G596V missense mutation in the STAT5B SH2 domain of the STAT5B-RARA.急性早幼粒细胞白血病，其STAT5B-RARA中存在STAT5B-RARA融合基因以及STAT5B SH2结构域中的G596V错义突变。
Eur J Haematol. 2009 Nov;83(5):499-501. doi: 10.1111/j.1600-0609.2009.01324.x. Epub 2009 Jul 18.
3
Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding.在G显带染色体17正常的急性早幼粒细胞白血病中检测STAT5B-RARA融合转录本
Eur J Haematol. 2008 May;80(5):444-7. doi: 10.1111/j.1600-0609.2008.01042.x. Epub 2008 Jan 23.
4
[DNA sequence analysis of a novel variate type of PML/RAR alpha fusion gene transcript].[一种新型PML/RARα融合基因转录变体类型的DNA序列分析]
Hunan Yi Ke Da Xue Xue Bao. 2001 Dec 28;26(6):581-2.
5
Acute promyelocytic leukaemia with cryptic PML-RARA fusion.伴有隐匿性PML-RARA融合的急性早幼粒细胞白血病
Br J Haematol. 2009 Apr;145(1):2. doi: 10.1111/j.1365-2141.2008.07437.x. Epub 2009 Nov 20.
6
Derivative (7)t(7;8): The sole karyotype abnormality in acute promyelocytic leukemia with PML/RARA rearrangement identified by RT-PCR and sequence analysis.衍生（7）t（7；8）：通过逆转录聚合酶链反应（RT-PCR）和序列分析确定的伴早幼粒细胞白血病中PML/RARA重排的唯一核型异常。
Leuk Res. 2009 Jul;33(7):e55-8. doi: 10.1016/j.leukres.2008.12.002. Epub 2009 Jan 21.
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deltaN-p73 is a transcriptional target of the PML/RARalpha oncogene in myeloid differentiation.δN-p73是髓系分化中PML/RARα癌基因的转录靶点。
Cell Death Differ. 2007 Nov;14(11):1968-71. doi: 10.1038/sj.cdd.4402210. Epub 2007 Aug 10.
8
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.通过降解PML-RARA根除急性早幼粒细胞白血病起始细胞。
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9
Masked t(15;17) APL with the insertion of PML-RARalpha fusion gene in 4q21.隐匿性t(15;17)急性早幼粒细胞白血病伴PML-RARα融合基因插入4q21。
Leuk Res. 2009 Nov;33(11):1552-5. doi: 10.1016/j.leukres.2009.04.033. Epub 2009 May 27.
10
Identification of atypical PML-RARA breakpoint in a patient with acute promyelocytic leukemia.急性早幼粒细胞白血病患者中非典型PML-RARA断点的鉴定。
Acta Haematol. 2007;118(3):183-7. doi: 10.1159/000109471. Epub 2007 Oct 11.

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Acute Promyelocytic Leukemia-like AML: Genetic Perspective and Clinical Implications.急性早幼粒细胞白血病样急性髓系白血病：遗传学视角与临床意义
Cancers (Basel). 2024 Dec 16;16(24):4192. doi: 10.3390/cancers16244192.
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Modulation of diverse biological processes by CPSF, the master regulator of mRNA 3' ends.CPSF 对多种生物过程的调节作用，CPSF 是 mRNA 3' 端的主要调节因子。
RNA. 2024 Aug 16;30(9):1122-1140. doi: 10.1261/rna.080108.124.
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Acute promyelocytic leukemia with FIP1L1::RARA fusion gene: The clinical utility of transcriptome sequencing and bioinformatic analyses.
伴有FIP1L1::RARA融合基因的急性早幼粒细胞白血病：转录组测序和生物信息学分析的临床应用
Front Oncol. 2023 Jan 26;12:1049473. doi: 10.3389/fonc.2022.1049473. eCollection 2022.
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EAHP 2020 workshop proceedings, pediatric myeloid neoplasms.EAHP 2020 研讨会论文集，小儿髓系肿瘤。
Virchows Arch. 2022 Oct;481(4):621-646. doi: 10.1007/s00428-022-03375-8. Epub 2022 Jul 11.
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Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis.APL样急性髓系白血病中的非典型重排：分子特征与预后
Front Oncol. 2022 Apr 12;12:871590. doi: 10.3389/fonc.2022.871590. eCollection 2022.
6
Successful treatment and integrated genomic analysis of an infant with FIP1L1-RARA fusion-associated myeloid neoplasm.成功治疗并进行综合基因组分析的一例婴儿 FIP1L1-RARA 融合相关性髓系肿瘤。
Blood Adv. 2022 Feb 22;6(4):1137-1142. doi: 10.1182/bloodadvances.2021004966.
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Alternative polyadenylation dysregulation contributes to the differentiation block of acute myeloid leukemia.可变聚腺苷酸化失调导致急性髓系白血病分化阻滞。
Blood. 2022 Jan 20;139(3):424-438. doi: 10.1182/blood.2020005693.
8
Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses.伴有RARA隐匿性插入FIP1L1的急性早幼粒细胞白血病髓系肉瘤：二代测序和生物信息学分析的临床应用
Front Oncol. 2021 Jun 24;11:688203. doi: 10.3389/fonc.2021.688203. eCollection 2021.
9
A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies.一种新型融合蛋白 TBLR1-RARα 作为癌基因诱导小鼠早幼粒细胞白血病：鉴定和治疗策略。
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