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[柔红霉素和阿霉素对结膜成纤维细胞增殖抑制作用的实验研究]

[Experimental study of the inhibitory effect of daunorubicin and doxorubicin in conjunctival fibroblast proliferation].

作者信息

Xu Y

机构信息

Henan Institute of Ophthalmology, Zhengzhou.

出版信息

Zhonghua Yan Ke Za Zhi. 1991 Mar;27(2):112-4.

PMID:1860403
Abstract

Both daunorubicin and doxorubicin were found effective in inhibiting proliferation of rabbit conjunctival fibroblasts in vitro. The 50% inhibition dose for daunorubicin was 0.14 micrograms/ml, and 0.46 micrograms/ml for doxorubicin, the former being stronger. The authors were hopeful that these drugs would prove useful in preventing cicatrization after glaucoma filter surgery.

摘要

柔红霉素和阿霉素在体外均能有效抑制兔结膜成纤维细胞的增殖。柔红霉素的50%抑制剂量为0.14微克/毫升,阿霉素为0.46微克/毫升,前者作用更强。作者希望这些药物能被证明对预防青光眼滤过术后的瘢痕形成有用。

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