维生素K3对兔成纤维细胞体外增殖的抑制作用。

The inhibition of vitamin K3 on rabbit fibroblast proliferation in vitro.

作者信息

Liu X H, Song X W, Xu Y, Zhang C

机构信息

Department of Ophthalmology, Henan Medical University, Zhengzhou, China.

出版信息

Ophthalmologica. 1996;210(3):180-2. doi: 10.1159/000310703.

DOI:10.1159/000310703

PMID:8738465

Abstract

Vitamin K3 that is commonly used to treat hemorrhagic diseases can inhibit human lymphatic neoplasms in vitro. This study was undertaken to investigate the effects of vitamin K3 on rabbit conjunctival fibroblast proliferation in cell culture. Vitamin K3 was added to cultured rabbit conjunctival fibroblasts. Remarkable inhibition was observed at a concentration of 4 mg/l. Because of its lower toxicity, vitamin K3 may prove to be of significant value in the treatment of intraocular proliferative disorders.

摘要

常用于治疗出血性疾病的维生素K3在体外可抑制人类淋巴瘤。本研究旨在探讨维生素K3对细胞培养中兔结膜成纤维细胞增殖的影响。将维生素K3添加到培养的兔结膜成纤维细胞中。在浓度为4毫克/升时观察到显著抑制作用。由于其毒性较低，维生素K3可能在眼内增殖性疾病的治疗中具有重要价值。