Hadjibabaie M, Iravani M, Taghizadeh M, Ataie-Jafari A, Shamshiri A R, Mousavi S A, Alimoghaddam K, Hosseini S, Ghavamzadeh A
Faculty of Pharmacy, Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Bone Marrow Transplant. 2008 Oct;42(7):469-73. doi: 10.1038/bmt.2008.188. Epub 2008 Jul 7.
The aims of this study were to establish the nutritional status of patients during hematopoietic SCT (HSCT) and to determine if body mass index (BMI) is a valid indicator of nutritional status in this population when compared with nitrogen balance (NB). In total, 50 patients were enrolled (mean age: 25.7+/-9.0 years). Patients (14%) were underweight (BMI<18.5 kg/m(2)), 58% in a normal BMI (between 18.5 and 24.9 kg/m(2)) and 28% were overweight or obese (BMI >or= 25 kg/m(2)). NB dropped after transplantation and increased from days +5 to +20 after transplantation (P=0.006). There was a significant negative relationship between patients' BMI and time to engraftment (r=-0.45, P=0.001). Engraftment of underweight patients was 3.0 days (P=0.002) and 4.0 days (P<0.001) later than in normal and overweight or obese patients, respectively. There was no significant correlation between NB before transplantation and time to engraftment (r=-0.22, P=0.16). The results of this study demonstrate that patients undergoing HSCT may have suboptimal nutritional status and that pre-HSCT-BMI rather than NB may have a greater correlation in HSCT patients with the time of engraftment. Therefore, it may be useful to consider patient's BMI before transplantation for earlier engraftment time.
本研究的目的是确定造血干细胞移植（HSCT）期间患者的营养状况，并与氮平衡（NB）相比，确定体重指数（BMI）是否是该人群营养状况的有效指标。总共纳入了50例患者（平均年龄：25.7±9.0岁）。患者中14%体重过轻（BMI<18.5 kg/m²），58%的BMI正常（介于18.5至24.9 kg/m²之间），28%超重或肥胖（BMI≥25 kg/m²）。移植后NB下降，在移植后第5天至第20天增加（P = 0.006）。患者的BMI与植入时间之间存在显著负相关（r = -0.45，P = 0.001）。体重过轻患者的植入时间分别比正常和超重或肥胖患者晚3.0天（P = 0.002）和4.0天（P<0.001）。移植前的NB与植入时间之间无显著相关性（r = -0.22，P = 0.16）。本研究结果表明，接受HSCT的患者可能营养状况欠佳，且HSCT患者移植前的BMI而非NB与植入时间的相关性可能更大。因此，考虑移植前患者的BMI以获得更早的植入时间可能是有用的。
