Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Biomedical Research Building II, Room 563-2, 4301 W. Markham Street, Little Rock, AR 72205, USA.
PPAR Res. 2008;2008:627463. doi: 10.1155/2008/627463.
The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-gamma agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This review will discuss the cellular and molecular mechanisms by which these agonists are believed to modulate disease. The therapeutic potential of PPAR-gamma agonists in the treatment of multiple sclerosis will also be considered.
过氧化物酶体增殖物激活受体 (PPARs) 在改变脂质和葡萄糖代谢中的作用已得到充分证实。最近的研究表明，PPARs 在控制免疫反应方面也起着关键作用。我们和其他人之前已经证明，PPAR-γ激动剂可调节实验性自身免疫性脑脊髓炎 (EAE) 的发展，EAE 是多发性硬化症 (MS) 的动物模型。这篇综述将讨论这些激动剂被认为调节疾病的细胞和分子机制。还将考虑 PPAR-γ激动剂在多发性硬化症治疗中的治疗潜力。
