炎症性肠病患者25-羟维生素D（25OHD）水平低下及其与骨密度的相关性

[Low levels of 25-hydroxyvitamin D (25OHD) in patients with inflammatory bowel disease and its correlation with bone mineral density].

作者信息

Souza Hevelyn Noemberg de, Lora Fabiana Lígia, Kulak Carolina A Moreira, Mañas Nádila Cecyn Pietszkowski, Amarante Heda M B, Borba Victória Z Cochenski

机构信息

Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná, PR, Brasil.

出版信息

Arq Bras Endocrinol Metabol. 2008 Jun;52(4):684-91. doi: 10.1590/s0004-27302008000400015.

DOI:10.1590/s0004-27302008000400015

PMID:18604382

Abstract

UNLABELLED

Patients with inflammatory bowel disease (IBD) are at risk of having vitamin D deficiency (25-OHD) and low bone mineral density (BMD).

OBJECTIVES

To measure 25OHD in a young group of IBD patients submitted to a clinical evaluation, routine biochemistry and BMD measurement (lumbar spine and proximal femur).

RESULTS

39 Crohn disease (CD) and 37 ulcerative colitis (UC) patients had lower serum levels of 25OHD compared to the control group (CD p = 0.003; UC p < 0.001), and 48.5% of the UC patients were 25OHD deficient. Lumbar spine BMD was lower in patients than controls (CD p = 0.001; UC p = 0.008). In CD patients, serum levels of 25OHD were significantly correlated with total femur (r = 0.391; p = 0.027) and femoral neck (r = 0.384; p = 0.03) BMD.

CONCLUSION

It was found lower levels of 25OHD and BMD in young IBD patients compared to normal controls, suggesting an important role of 25OHD deficiency in the pathogenesis of the IBD bone disease.

摘要

未标注

炎症性肠病（IBD）患者存在维生素D缺乏（25-OHD）和低骨矿物质密度（BMD）的风险。

目的

对一组接受临床评估、常规生化检查和BMD测量（腰椎和股骨近端）的年轻IBD患者测量25OHD。

结果

与对照组相比，39例克罗恩病（CD）患者和37例溃疡性结肠炎（UC）患者的血清25OHD水平较低（CD p = 0.003；UC p < 0.001），48.5%的UC患者存在25OHD缺乏。患者的腰椎BMD低于对照组（CD p = 0.001；UC p = 0.008）。在CD患者中，血清25OHD水平与全股骨（r = 0.391；p = 0.027）和股骨颈（r = 0.384；p = 0.03）BMD显著相关。