Souza Hevelyn Noemberg de, Lora Fabiana Lígia, Kulak Carolina A Moreira, Mañas Nádila Cecyn Pietszkowski, Amarante Heda M B, Borba Victória Z Cochenski
Serviço de Endocrinologia e Metabologia, Hospital de Clínicas, Universidade Federal do Paraná, PR, Brasil.
Arq Bras Endocrinol Metabol. 2008 Jun;52(4):684-91. doi: 10.1590/s0004-27302008000400015.
Patients with inflammatory bowel disease (IBD) are at risk of having vitamin D deficiency (25-OHD) and low bone mineral density (BMD).
To measure 25OHD in a young group of IBD patients submitted to a clinical evaluation, routine biochemistry and BMD measurement (lumbar spine and proximal femur).
39 Crohn disease (CD) and 37 ulcerative colitis (UC) patients had lower serum levels of 25OHD compared to the control group (CD p = 0.003; UC p < 0.001), and 48.5% of the UC patients were 25OHD deficient. Lumbar spine BMD was lower in patients than controls (CD p = 0.001; UC p = 0.008). In CD patients, serum levels of 25OHD were significantly correlated with total femur (r = 0.391; p = 0.027) and femoral neck (r = 0.384; p = 0.03) BMD.
It was found lower levels of 25OHD and BMD in young IBD patients compared to normal controls, suggesting an important role of 25OHD deficiency in the pathogenesis of the IBD bone disease.
炎症性肠病（IBD）患者存在维生素D缺乏（25-OHD）和低骨矿物质密度（BMD）的风险。
对一组接受临床评估、常规生化检查和BMD测量（腰椎和股骨近端）的年轻IBD患者测量25OHD。
与对照组相比，39例克罗恩病（CD）患者和37例溃疡性结肠炎（UC）患者的血清25OHD水平较低（CD p = 0.003；UC p < 0.001），48.5%的UC患者存在25OHD缺乏。患者的腰椎BMD低于对照组（CD p = 0.001；UC p = 0.008）。在CD患者中，血清25OHD水平与全股骨（r = 0.391；p = 0.027）和股骨颈（r = 0.384；p = 0.03）BMD显著相关。
与正常对照组相比，年轻IBD患者的25OHD和BMD水平较低，提示25OHD缺乏在IBD骨病发病机制中起重要作用。
