Byne William, Hazlett Erin A, Buchsbaum Monte S, Kemether Eileen
Department of Psychiatry, James J Peters VA Medical Center, Research Bldg. Room 2F39, Bronx, NY 10468, USA.
Acta Neuropathol. 2009 Apr;117(4):347-68. doi: 10.1007/s00401-008-0404-0. Epub 2008 Jul 5.
The thalamus provides a nodal link for multiple functional circuits that are impaired in schizophrenia (SZ). Despite inconsistencies in the literature, a meta analysis suggests that the volume of the thalamus relative to that of the brain is decreased in SZ. Morphometric neuroimaging studies employing deformation, voxel-based and region of interest methodologies suggest that the volume deficit preferentially affects the thalamic regions containing the anterior and mediodorsal nuclei, and the pulvinar. Postmortem design-based stereological studies have produced mixed results regarding volume and neuronal deficits in these nuclei. This review examines those aspects of thalamic circuitry and function that suggest salience to SZ. Evidence for anomalies of thalamic structure and function obtained from postmortem and neuroimaging studies is then examined and directions for further research proposed.
丘脑为精神分裂症（SZ）中受损的多个功能回路提供了一个节点连接。尽管文献中存在不一致之处，但一项荟萃分析表明，SZ患者丘脑体积与脑体积之比降低。采用变形、基于体素和感兴趣区域方法的形态计量神经影像学研究表明，体积减少优先影响包含前核和背内侧核以及丘脑枕的丘脑区域。基于尸检设计的立体学研究在这些核的体积和神经元缺陷方面产生了混合结果。本综述探讨了丘脑回路和功能中与SZ相关的那些方面。然后检查了从尸检和神经影像学研究中获得的丘脑结构和功能异常的证据，并提出了进一步研究的方向。
