Bossé Ynuk, Paré Peter D, Seow Chun Y
James Hogg iCAPTURE Centre/St. Paul's Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.
Curr Allergy Asthma Rep. 2008 Jul;8(4):357-66. doi: 10.1007/s11882-008-0056-0.
Asthma is an episodic respiratory syndrome caused by several pathogenic processes. This recurrent syndrome is associated with an accelerated decline in lung function and increase in airway obstruction over time. The reduced lung function is a consequence of tissue restructuring of all the components of the airway wall: 1) epithelium metaplasia; 2) altered quantity, composition, and distribution of extracellular matrix components; 3) microvascular remodeling; and 4) increase of airway smooth muscle mass. How these structural changes affect lung functions is not entirely clear. Deeper understandings of the altered structure and related functional impairment are important for gaining insights into the mechanisms underlying asthma. This review describes the tissue remodeling observed in different compartments of the asthmatic airway wall, from the airway lumen to adventitia. The underlying mechanisms driving the remodeling processes are also briefly reviewed.
哮喘是一种由多种致病过程引起的发作性呼吸综合征。这种复发性综合征与肺功能的加速下降以及随着时间推移气道阻塞的增加有关。肺功能下降是气道壁所有组成部分组织重构的结果：1）上皮化生；2）细胞外基质成分的数量、组成和分布改变；3）微血管重塑；4）气道平滑肌质量增加。这些结构变化如何影响肺功能尚不完全清楚。深入了解结构改变和相关功能损害对于深入了解哮喘的潜在机制很重要。本综述描述了在哮喘气道壁从气道腔到外膜的不同区域观察到的组织重塑。还简要回顾了驱动重塑过程的潜在机制。
