Nayak Ajay P, Deshpande Deepak A, Penn Raymond B
Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, USA.
F1000Res. 2018 May 30;7. doi: 10.12688/f1000research.14581.1. eCollection 2018.
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). The pathology manifests itself in the form of significant, progressive, and (to date) seemingly irreversible changes to distinct respiratory structural compartments. Consequently, AR correlates with disease severity and the gradual decline in pulmonary function associated with asthma and COPD. Although current asthma/COPD drugs manage airway contraction and inflammation, none of these effectively prevent or reverse features of AR. In this review, we provide a brief overview of the features and putative mechanisms affecting AR. We further discuss recently proposed strategies with promise for deterring or treating AR.
气道重塑（AR）是阻塞性肺疾病（包括哮喘和慢性阻塞性肺疾病（COPD））的一种进行性病理特征。其病理表现为不同呼吸结构腔室出现显著、进行性且（迄今为止）似乎不可逆的变化。因此，AR与疾病严重程度以及哮喘和COPD相关的肺功能逐渐下降有关。尽管目前的哮喘/COPD药物可控制气道收缩和炎症，但这些药物均无法有效预防或逆转AR的特征。在本综述中，我们简要概述了影响AR的特征和假定机制。我们还进一步讨论了最近提出的有望阻止或治疗AR的策略。
