Nackaerts O, Jacobs R, Devlin H, Pavitt S, Bleyen E, Yan B, Borghs H, Lindh C, Karayianni K, van der Stelt P, Marjanovic E, Adams J E, Horner K
Oral Imaging Center, Department of Dentistry, Faculty of Medicine, KU Leuven, Belgium.
Dentomaxillofac Radiol. 2008 Jul;37(5):282-7. doi: 10.1259/dmfr/30424604.
To determine the diagnostic accuracy of mandibular and maxillary bone density in detecting osteoporosis using receiver operating characteristic (ROC) analysis.
671 women between 45 years and 70 years of age underwent dual energy X-ray absorptiometry (DXA) of the hip and lumbar spine. This was the gold standard for diagnosing osteoporosis. Intraoral radiography of the upper and lower right premolar region was performed, using an aluminium wedge as a densitometric reference. Jaw bone density was determined using dedicated software. Observer differences and ROC curves were analysed.
For detecting osteoporosis using jaw bone density, the area under the ROC curve (A(z)) was 0.705. For separate analysis of mandibular and maxillary films, sensitivity varied from 33.9% to 38.7% and specificity from 83.5% to 85.3% when using a threshold of 4.3 mm Al equivalent.
Density of the premolar region reaches a fair diagnostic accuracy, which might improve when including additional factors in the analysis and refining the densitometric tool.
采用受试者工作特征(ROC)分析确定下颌骨和上颌骨密度在检测骨质疏松症中的诊断准确性。
对671名年龄在45岁至70岁之间的女性进行了髋部和腰椎的双能X线吸收测定法(DXA)。这是诊断骨质疏松症的金标准。使用铝楔作为密度测定参考,对上下右前磨牙区域进行口腔内放射摄影。使用专用软件测定颌骨密度。分析观察者差异和ROC曲线。
使用颌骨密度检测骨质疏松症时,ROC曲线下面积(A(z))为0.705。在使用4.3毫米铝当量阈值对下颌和上颌X线片进行单独分析时,灵敏度在33.9%至38.7%之间,特异性在83.5%至85.3%之间。
前磨牙区域的密度达到了一定的诊断准确性,在分析中纳入其他因素并改进密度测定工具时,诊断准确性可能会提高。