Ylikoski J, Mrena R, Makitie A, Kuokkanen J, Pirvola U, Savolainen S
Helsinki Ear Institute and Department of Otolaryngology, University of Helsinki, Helsinki, Finland.
Acta Otolaryngol. 2008 Oct;128(10):1110-5. doi: 10.1080/00016480801901634.
The average recovery of hearing and cessation of tinnitus was significantly better after hyperbaric oxygen therapy (HBOT) than after normobaric oxygen therapy (NBOT). HBOT can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT).
AAT was one of the early indications for the use of HBOT. The rationale of administering oxygen to patients with AAT is based on experimental studies showing that noise exposure results in cochlear hypoxia, which could be compensated by HBOT. The aim of this study was to investigate the efficacy of HBOT in patients with AAT.
We compared the recovery from hearing impairment and tinnitus in 60 ears treated with HBOT with 60 ears treated with NBOT. The HBOT was given daily for 1-8 days. There were no significant differences in clinical or audiological data between HBOT and NBOT groups.
The average recovery of hearing both at high and speech frequencies was significantly better and tinnitus persisted less commonly after the HBOT than after the NBOT. Normal hearing at the end of the follow-up period was regained in 42 ears in the HBOT group and in 24 ears in the NBOT group (p<0.01).
高压氧治疗(HBOT)后听力的平均恢复情况及耳鸣停止情况显著优于常压氧治疗(NBOT)。HBOT对于急性声创伤(AAT)患者而言是一种有价值的辅助治疗方法。
AAT是HBOT使用的早期指征之一。对AAT患者给予氧气治疗的理论依据基于实验研究,该研究表明噪声暴露会导致耳蜗缺氧,而HBOT可对此进行补偿。本研究的目的是调查HBOT对AAT患者的疗效。
我们比较了60只接受HBOT治疗的耳朵与60只接受NBOT治疗的耳朵在听力损伤和耳鸣方面的恢复情况。HBOT每天进行,持续1 - 8天。HBOT组和NBOT组在临床或听力学数据方面无显著差异。
与NBOT相比,HBOT后高频和言语频率的听力平均恢复情况显著更好,耳鸣持续的情况也更少。随访期结束时,HBOT组42只耳朵恢复了正常听力,NBOT组24只耳朵恢复了正常听力(p<0.01)。