Gatto Nicole M, Henderson Victor W, St John Jan A, McCleary Carol, Hodis Howard N, Mack Wendy J
Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA 90089-9010, USA.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2008 Sep;15(5):627-41. doi: 10.1080/13825580802036936. Epub 2008 May 16.
Few studies have addressed whether the metabolic syndrome (MetS) and its individual components are associated with cognitive function in middle-aged and older populations, as well as whether specific areas of cognition are more affected than others. We examined the cross-sectional association between MetS and six areas of cognitive function in healthy cognitively intact adults without diabetes (n = 853, mean age 61 years) randomized in two intervention trials.
The National Cholesterol Education Program (NCEP) criteria were used to identify subjects with MetS. Cognitive function was assessed with a neuropsychological battery. A principal components analysis was used to extract five uncorrelated factors interpreted to represent five areas of cognition, and a measure of global cognition was calculated.
MetS was weakly but non-significantly associated with lower verbal learning (beta = -.14 [SE(beta) = 0.09], p = .15). As the number of MetS criteria increased, scores on global cognition (p trend = .01), verbal learning (p trend = .06) and semantic memory (p trend = .04) decreased. Hypertension was the only MetS risk factor that was independently correlated with lower verbal learning (beta = -.17 [SE(beta) = 0.08], p = .04), semantic memory (beta = -.26 [SE(beta) = 0.08], p = .001) and global cognition (beta = -.15 [SE(beta) = 0.07], p = .04).
This study adds to the evidence of an association between MetS and lower cognitive function among healthy middle-aged and older adults without CVD and diabetes, as well as confirms the correlation between hypertension and lower cognition.
很少有研究探讨代谢综合征（MetS）及其各个组成部分是否与中老年人群的认知功能相关，以及特定认知领域是否比其他领域受影响更大。我们在两项干预试验中，对无糖尿病的健康认知功能正常的成年人（n = 853，平均年龄61岁）进行了研究，考察了MetS与六个认知功能领域之间的横断面关联。
采用美国国家胆固醇教育计划（NCEP）标准来识别患有MetS的受试者。使用一套神经心理测试组合来评估认知功能。通过主成分分析提取五个不相关的因素，解释为代表五个认知领域，并计算整体认知的指标。
MetS与较低的言语学习能力呈弱相关但无统计学意义（β = -0.14 [标准误（β）= 0.09]，p = 0.15）。随着MetS标准数量的增加，整体认知（p趋势 = 0.01）、言语学习（p趋势 = 0.06）和语义记忆（p趋势 = 0.04）的得分下降。高血压是唯一与较低的言语学习能力（β = -0.17 [标准误（β）= 0.08]，p = 0.04）、语义记忆（β = -0.26 [标准误（β）= 0.08]，p = 0.001）和整体认知（β = -0.15 [标准误（β）= 0.07]，p = 0.04）独立相关的MetS危险因素；
本研究补充了证据，表明在无心血管疾病和糖尿病的健康中老年成年人中，MetS与较低的认知功能之间存在关联，同时也证实了高血压与较低认知之间的相关性。
