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Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems.

作者信息

Abuwatfa Waad H, Awad Nahid S, Pitt William G, Husseini Ghaleb A

机构信息

Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.

Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.

出版信息

Polymers (Basel). 2022 Feb 25;14(5):925. doi: 10.3390/polym14050925.

DOI:10.3390/polym14050925
PMID:35267747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8912701/
Abstract

Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/8fe455c8a3d8/polymers-14-00925-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/9595e05230c9/polymers-14-00925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/579190875234/polymers-14-00925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/04e0b8b95359/polymers-14-00925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/18f2402d4ac4/polymers-14-00925-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/d826fdbec9ca/polymers-14-00925-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/ac1655e8ba4c/polymers-14-00925-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/bea40b4aac78/polymers-14-00925-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/448058f91bee/polymers-14-00925-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/8fe455c8a3d8/polymers-14-00925-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/9595e05230c9/polymers-14-00925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/579190875234/polymers-14-00925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/04e0b8b95359/polymers-14-00925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/18f2402d4ac4/polymers-14-00925-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/d826fdbec9ca/polymers-14-00925-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/ac1655e8ba4c/polymers-14-00925-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/bea40b4aac78/polymers-14-00925-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/448058f91bee/polymers-14-00925-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/306a/8912701/8fe455c8a3d8/polymers-14-00925-g009.jpg

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[10]
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引用本文的文献

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Int J Mol Sci. 2025-7-29

[2]
Dual-Drug Delivery Systems Using Hydrogel-Nanoparticle Composites: Recent Advances and Key Applications.

Gels. 2025-7-3

[3]
Effects of the mitoxantrone thermosensitive liposome nanodelivery system on prostate cancer in vivo and in vitro.

Sci Rep. 2025-5-7

[4]
Nanocarriers for cutting-edge cancer immunotherapies.

J Transl Med. 2025-4-16

[5]
The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases.

Discov Nano. 2025-1-30

[6]
Liposomal Formulations: A Recent Update.

Pharmaceutics. 2024-12-30

[7]
Innovative Approaches to Enhancing the Biomedical Properties of Liposomes.

Pharmaceutics. 2024-11-27

[8]
Influence of Composition on the Patterns of Electrokinetic Potential of Thermosensitive N-(Isopropyl)Acrylamide Derivatives with Poly(Ethylene Glycol) Dimethacrylate and N-(2-Hydroxyethyl)Acrylamide.

Int J Mol Sci. 2024-12-18

[9]
Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.

Bioengineered. 2024-12

[10]
Stimuli-Responsive Liposomes of 5-Fluorouracil: Progressive Steps for Safe and Effective Treatment of Colorectal Cancer.

Pharmaceutics. 2024-7-22

本文引用的文献

[1]
Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations.

Polymers (Basel). 2021-12-15

[2]
Turning down the heat: The case for mild hyperthermia and thermosensitive liposomes.

Nanomedicine. 2022-2

[3]
Investigating the Application of Liposomes as Drug Delivery Systems for the Diagnosis and Treatment of Cancer.

Int J Biomater. 2021-9-1

[4]
Chemical-Physical Behaviour of Microgels Made of Interpenetrating Polymer Networks of PNIPAM and Poly(acrylic Acid).

Polymers (Basel). 2021-4-21

[5]
Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review.

ACS Pharmacol Transl Sci. 2021-3-3

[6]
Ultrasound-triggered herceptin liposomes for breast cancer therapy.

Sci Rep. 2021-4-6

[7]
Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles.

Polymers (Basel). 2021-3-26

[8]
Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound.

J Biomed Nanotechnol. 2021-1-1

[9]
Liposomes: Biomedical Applications.

Chonnam Med J. 2021-1

[10]
Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer.

Polymers (Basel). 2021-1-21

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