从组成到治疗：抗癌药物载体的系统工程方法。
From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.
机构信息
Department of Biomedical Engineering, Duke University, P.O. Box 90281, Durham, NC, 27708, USA.
Research Triangle MRSEC, Durham, NC, 27708, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6712-6733. doi: 10.1002/anie.201610819. Epub 2017 May 2.
The molecular complexity and heterogeneity of cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease. The pharmaceutical industry focuses the bulk of its efforts on the development of new drugs, but an alternative approach is to improve the delivery of existing drugs with drug carriers that can manipulate when, where, and how a drug exerts its therapeutic effect. For the treatment of solid tumors, systemically delivered drug carriers face significant challenges that are imposed by the pathophysiological barriers that lie between their site of administration and their site of therapeutic action in the tumor. Furthermore, drug carriers face additional challenges in their translation from preclinical validation to clinical approval and adoption. Addressing this diverse network of challenges requires a systems engineering approach for the rational design of optimized carriers that have a realistic prospect for translation from the laboratory to the patient.
癌症的分子复杂性和异质性导致了一个持续存在且尚未解决的挑战，即开发治疗这种疾病的方法。制药行业将大部分精力集中在开发新药上，但另一种方法是通过药物载体来提高现有药物的递送效率，药物载体可以控制药物何时、何地以及如何发挥治疗效果。对于实体瘤的治疗，系统给药的药物载体面临着重大挑战，这些挑战是由给药部位与肿瘤治疗部位之间的病理生理学屏障所施加的。此外，药物载体在从临床前验证到临床批准和采用的过程中还面临着额外的挑战。要解决这一系列挑战，需要采用系统工程方法来合理设计优化的载体，使它们具有从实验室向患者转化的现实前景。
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