α-肾上腺素能受体阻断增加人类快速眼动睡眠。
Apha-adrenergic receptor blockade increases human REM sleep.
作者信息
Oswald I, Thacore V R, Adam K, Brezinová V
出版信息
Br J Clin Pharmacol. 1975 Apr;2(2):107-10. doi: 10.1111/j.1365-2125.1975.tb01565.x.
Abstract
1 An alpha-adrenergic receptor blocking agent, thymoxamine (150 mg i.v.) in the early night sleep of young adults increased REM sleep duration and also brief awakenings in the early night, while slow wave sleep, stage 3+4, was diminished. In the later night, however, stage 3+4 sleep was increased. Control experiments demonstrated that thymoxamine (i.v.) was without effect on blood pressure. 2 REM sleep duration may be inversely proportional to noradrenaline available at central alpha-adrenoceptors, but the control mechanisms for REM sleep appear interdependent with those for NREM sleep.
摘要
- 一种α-肾上腺素能受体阻断剂，百里胺（静脉注射150毫克），在年轻成年人的夜间早期睡眠中增加了快速眼动睡眠持续时间，同时也增加了夜间早期的短暂觉醒，而慢波睡眠，即3+4期睡眠，则减少了。然而，在夜间后期，3+4期睡眠增加了。对照实验表明，百里胺（静脉注射）对血压没有影响。2. 快速眼动睡眠持续时间可能与中枢α-肾上腺素能受体处可用的去甲肾上腺素成反比，但快速眼动睡眠的控制机制似乎与非快速眼动睡眠的控制机制相互依存。
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