一种抗组胺药——异丙嗪的催眠作用。
The hypnotic effects of an antihistamine: promethazine.
作者信息
Adam K, Oswald I
出版信息
Br J Clin Pharmacol. 1986 Dec;22(6):715-7. doi: 10.1111/j.1365-2125.1986.tb02962.x.
Abstract
Twelve volunteer poor sleepers of mean age 59 years took placebo on one night, promethazine 20 mg on one night and promethazine 40 mg on one night, in a double-blind balanced order study. Sleep in the EEG laboratory was increased by nearly 1 h after either dose of promethazine, and sleep interruptions were reduced. Slow-wave sleep was unaffected, but the larger dose reduced the percentage of sleep spent as REM sleep. Sleep was improved subjectively by both doses of promethazine which appears to be an effective hypnotic.
摘要
在一项双盲均衡试验研究中，12名平均年龄59岁的志愿睡眠不佳者，在三个晚上分别服用安慰剂、20毫克异丙嗪和40毫克异丙嗪。服用任一剂量的异丙嗪后，在脑电图实验室的睡眠时间增加了近1小时，睡眠中断减少。慢波睡眠未受影响，但较大剂量降低了快速眼动睡眠在总睡眠时间中所占的百分比。两种剂量的异丙嗪在主观上都改善了睡眠，它似乎是一种有效的催眠药。
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